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Synthesis and characterization of gadolinium nanostructured materials with potential applications in magnetic resonance imaging, neutron-capture therapy and targeted drug delivery

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Abstract

Two Gadolinium nanostructured materials, Gd2(OH)5NO3 nanoparticles and Gd(OH)3 nanorods, were synthesized and extensively characterized by various techniques. In addition to the potential use of Gd2(OH)5NO3 in magnetic resonance imaging (MRI) and Neutron-capture therapy (NCT) application, it could also be used in targeted drug delivery. An antibiotic (nalidixic acid), two amino acids (aspartic and glutamic acid), a fatty acid and a surfactant (SDS) were intercalated in the nanoparticles. The surface of the nanoparticles was modified with folic acid in order to be capable of targeted delivery to folate receptor expressing sites, such as tumor human cells.

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Acknowledgments

This work was part of the 03ED375 research project, implemented within the framework of the “Reinforcement Programme of Human Research Manpower” (PENED) and co-financed by National and Community Funds (25% from the Greek Ministry of Development-General Secretariat of Research and Technology and 75% from E.U.-European Social Fund). The authors would like to thank Dr. A. Lappas (IESL Crete) for the magnetic measurements, Mrs A. Tsagkaraki (University of Crete) for the AFM studies, the Polymer & Colloid Science Group as well as the NanoComplex Materials staff of IESL of Crete for XRD measurements. Finally, we would like to thank the staff of the microscope lab of the Biology department (University of Crete).

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  1. Department of Chemistry, University of Crete, 71003, Voutes, Heraklion, Greece

    Dimitrios Stefanakis & Demetrios F. Ghanotakis

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  1. Dimitrios Stefanakis
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  2. Demetrios F. Ghanotakis
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Correspondence to Demetrios F. Ghanotakis.

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Stefanakis, D., Ghanotakis, D.F. Synthesis and characterization of gadolinium nanostructured materials with potential applications in magnetic resonance imaging, neutron-capture therapy and targeted drug delivery. J Nanopart Res 12, 1285–1297 (2010). https://doi.org/10.1007/s11051-010-9848-y

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