Skip to main content
SpringerLink
Log in

The Nanotoxicology Research Program in NIOSH

  • Nanoparticles and Occupational Health
  • Published:
Journal of Nanoparticle Research Aims and scope Submit manuscript

Abstract

The National Institute for Occupational Safety and Health through its Nanotechnology Research Center has developed a Strategic Plan for Nanotechnology Safety and Health Research. This Strategic Plan identified knowledge gaps and critical issues, which must be addressed to protect the health and safety of workers producing nanoparticles as well as those incorporating nanoparticles into commercial products or using nanomaterials in novel applications. This manuscript lists the projects that comprise the Nanotoxicology Program in NIOSH and provides a brief description of the goals and accomplishments of these projects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Barrett JC, Lamb PW, Wiseman RW (1989) Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers. Environ Health Perspect 81:81–89

    Article  PubMed  CAS  Google Scholar 

  • Ding M, Lu Y, Bowman L, Leonard S, Castranova V, Vallyathan V (2006) Titanium nanoparticles induce AP-1 activation through ROS and MAPKs pathways. In: Proceedings of the first international conference on toxicology of nanomaterials: biomedical aspects. Miami, 29 January–1 February, 2006, p 101

  • Dockery DW, Pope CA, Xu X, Spengler JD, Ware SH, Fay ME, Ferris BG, Speizer FE (1995) Mortality risks of air pollution: a prospective cohort study. New Engl J Med 329:1953–1759

    Google Scholar 

  • Gorelik O, Nikolaev P, Arepulli S (2000) Purification procedures for single-walled carbon nanotubes. NASA Contractor Report. NASA/CR – 2000-208926

  • Li Z, Hulderman T, Salman R, Chapman R, Leonard SS, Yong S-H, Shvedova A, Luster MI, Simeonova PP (2007) Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes. Environ Health Perspect 115:377–382

    PubMed  CAS  Google Scholar 

  • Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V (2004) Exposure to carbon nanotube material during the handling of unrefined single walled carbon nanotube material. J Toxicol Environ Health Part A 67:87–107

    Article  PubMed  CAS  Google Scholar 

  • Mercer RR, Scabilloni J, Wang L, Kisin E, Murray AR, Schwegler-Berry D, Shvedova AA, Castranova V (2007) Alternation of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model. Am J Physiol Lung Cell Mol Physiol. doi:10.1152/ajplun.00186.2007

  • Murray AR, Kisin E, Kommineni C, Kagen VE, Castranova V, Shvedova AA (2007) Single-walled carbon nanotubes induce oxidative stress and inflammation in skin. Toxicologist 91:A1406

    Google Scholar 

  • Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627

    Article  PubMed  ADS  CAS  Google Scholar 

  • Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA (2004) Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 112:1299–1306

    PubMed  CAS  Google Scholar 

  • Nurkiewicz TR, Porter DW, Barger M, Millecchia L, Rao KM, Marvar PJ, Hubbs AF, Castranova V, Boegehold M (2006) Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure. Environ Health Perspect 114:412–419

    Article  PubMed  Google Scholar 

  • Nurkiewicz TR, Porter DW, Hubbs AF, Cumpston JL, Chen BT, Frazer DG, Castranova V (2008) Nanoparticle inhalation augments particle dependent systemic microvascular dysfunction. Part Fibre Toxicol 5:1. doi:10 1186/1743-8977-5-1

    Article  PubMed  CAS  Google Scholar 

  • Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839

    Article  PubMed  CAS  Google Scholar 

  • Oshimura M, Hesterberg TW, Tsutsui T, Barrett JC (1984) Correlation of asbestos-induced cytogentic effects with cell transformation of Syrian hamster embryo cells in culture. Cancer Res 44:5017–5022

    PubMed  CAS  Google Scholar 

  • Pope CA, Thun MS, Namboodiri MM, Dockery DW, Evans JS, Speizer FE, Health CW (1995) Particulate air pollution as a predictor of mortality in a prospective study of US adults. Am J Respir Crit Care Med 151:669–674

    PubMed  Google Scholar 

  • Porter DW, Holian A, Sriram K, Wu N, Wolfarth M, Hamilton R, Buford M (2008) Engineered titanium dioxide nanowire toxicity in vitro and in vivo. Toxicologist 102:A1492

    Google Scholar 

  • Roco MC (2004) Science and technology integration for increased human potential and societal outcomes. Ann NY Acad Sci 1013:1–6

    Article  PubMed  ADS  Google Scholar 

  • Sager T, Porter D, Robinson V, Lindsley WG, Schwegler-Berry DE, Castranova V (2007) An improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity. Nanotoxicology 1:118–129

    Article  CAS  Google Scholar 

  • Sager T, Porter DW, Castranova V (2008) Pulmonary response to intratracheal instillation of fine or ultrafine carbon black or titanium dioxide: role of surface area. Toxicologist 102:A1491

    Google Scholar 

  • Shvedova AA, Kisin ER, Murray AR, Schwegler-Berry D, Gandelsman VZ, Maynard A, Baron P, Castranova V (2003) Exposure to carbon nanotube material: assessment of the biological effects of nanotube materials using human keratinocytes. J Toxicol Environ Health Part A 66:1901–1926

    Article  Google Scholar 

  • Shvedova AA, Kisin E, Murray A, Schwegler-Berry D, Gandelsman VZ, Baron P, Maynard A, Gunter MR, Castranova V (2004) Exposure of human bronchial epithelial cells to carbon nanotubes caused oxidative stress and cytotoxicity. In: Proceedings of the society of free radical research meeting, Ioannina, Greece, 26–29 June 2003, pp 91–103

  • Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler-Berry D, Hubbs AF, Antonini J, Evans DE, Ku B-K, Ramey D, Maynard A, Kagan VE, Castranova V, Baron P (2005) Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:698–708

    Article  CAS  Google Scholar 

  • Shvedova AA, Sager T, Murray A, Kisin E, Porter DW, Leonard SS, Schwegler-Berry D, Robinson VA, Castranova V (2007a) Critical issues in the evaluation of possible effects resulting from airborne nanoparticles. In: Monteiro-Riviere N, Tran L (eds) Nanotechnology: characterization, dosing, and health effects chap 14. Informa Healthcare, Philadelphia, pp 221–232

  • Shvedova AA, Kisin ER, Murray AR, Gorelik O, Arepalli S, Castranova V, Young S-H, Gao F, Tyurina YY, Oury TD, Kagan V (2007b) Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57Bl/6 mice. Toxicol Appl Pharmacol 221:339–348

    Article  PubMed  CAS  Google Scholar 

  • Shvedova AA, Fabisiak JP, Kisin ER, Murray AR, Robert JR, Antonini JA, Kommineni C, Reynolds J, Barchowsky A, Castranova V, Kagan V (2008a) Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am J Respir Cell Mol Biol 38:579–590

  • Shvedova AA, Kisin E, Murray AR, Johnson V, Gorelik O, Arepalli S, Hubbs AF, Mercer RR, Stone S, Frazer D, Chen T-H, Deye G, Maynard, A, Baron P, Mason R, Kadiiska M, Stadler K, Mouithys-Mickadlad A, Castranova V, Kagan VE (2008b) Inhalation of carbon nanotubes induces oxidative stress and cytokine response causing respiratory impairment and pulmonary fibrosis in mice. Toxicologist 102:A1497

  • Sriram K, Porter DW, Tsuruoka S, Endo M, Jefferson AM, Wolfarth MG, Roger GM, Castranova V, Luster MI (2007) Neuroinflammatory response following exposure to engineered nanomaterials. Toxicologist 96:A1390

    Google Scholar 

  • Wang L, Castranova V, Rojanaskul Y, Lu Y, Scabilloni JF, Mercer RR (2008) Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts. Toxicologist 102:A1499

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA

    Vincent Castranova

Authors
  1. Vincent Castranova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vincent Castranova.

Additional information

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessary represent the views of the National Institute for Occupational Safety and Health.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Castranova, V. The Nanotoxicology Research Program in NIOSH. J Nanopart Res 11, 5–13 (2009). https://doi.org/10.1007/s11051-008-9421-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11051-008-9421-0

Keywords

Search

Navigation