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The First Case of Invasive Mixed-Mold Infections Due to Emericella nidulans var. echinulata and Rasamsonia piperina in a Patient with Chronic Granulomatous Disease

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Abstract

A 16-year-old boy with chronic granulomatous disease presented with pneumonia and rib osteomyelitis. Emericella nidulans var. echinulata was isolated from his sputum. After starting voriconazole, Rasamsonia piperina was isolated from the rib swelling. A combination therapy of voriconazole and micafungin effectively eradicated this invasive mixed-mold infection. In immunocompromised patients, a precise pathogenic diagnosis is clinically useful for administration of an appropriate treatment regimen.

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Acknowledgments

The authors greatly appreciate the assistance of Kyoko Yarita for analyzing the fungal isolates.

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Authors and Affiliations

  1. Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan

    Naruhiko Ishiwada, Noriko Takeuchi, Akira Watanabe & Katsuhiko Kamei

  2. Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan

    Kenichi Takeshita, Koo Nagasawa, Haruka Hishiki & Naoki Shimojo

  3. Division of Bioresources, Medical Mycology Research Center, Chiba University, Chiba, Japan

    Takashi Yaguchi

Authors
  1. Naruhiko Ishiwada
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  2. Kenichi Takeshita
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  3. Takashi Yaguchi
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  4. Koo Nagasawa
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  5. Noriko Takeuchi
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  6. Haruka Hishiki
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  7. Akira Watanabe
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  8. Katsuhiko Kamei
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  9. Naoki Shimojo
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Correspondence to Naruhiko Ishiwada.

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Ishiwada, N., Takeshita, K., Yaguchi, T. et al. The First Case of Invasive Mixed-Mold Infections Due to Emericella nidulans var. echinulata and Rasamsonia piperina in a Patient with Chronic Granulomatous Disease. Mycopathologia 181, 305–309 (2016). https://doi.org/10.1007/s11046-015-9963-5

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  • DOI: https://doi.org/10.1007/s11046-015-9963-5

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