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Urinary Tract Infection (UTI) Caused by Fusarium proliferatum in an Agranulocytosis Patient and a Review of Published Reports

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Abstract

Infections caused by Fusarium species are increasing in frequency among immunocompromised hosts, but urinary tract infection (UTI) due to Fusarium proliferatum has not been reported in the literature so far. We describe a case of UTI caused by F. proliferatum in a 47-year-old man who was diagnosed with rectal cancer and metastasis. He underwent radical resection of rectal carcinoma and local resection of hepatic metastases. After the first adjuvant chemotherapy, the patient presented the obvious high fever, severely diarrhea and progressive decline of the white blood cell count. The direct microscopic examination of fungi in urine was positive, and the fungal cultures showed white, cotton-like colony. After the DNA sequencing, it was identified as F. proliferatum. We gave the patient itraconazole and other antibiotics to fight the infection. A month later, the temperature dropped to normal and the results of the direct microscopic examination and culture of fungi in urine turn negative. The itraconazole is effective against F. proliferatum.

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References

  1. Eleni IB, Elias JA. Fusarium, a significant emerging pathogen in patients with hematologic malignancy: ten years’ experience at a cancer center and implications for management. Blood. 1997;90:999.

    Google Scholar 

  2. Musial CE, Cockerill FR, Roberts GD. Fungal infections of the immunocompromised host: clinical and laboratory aspects. Clin Microbiol Rev. 1988;1:349–64.

    PubMed Central  CAS  PubMed  Google Scholar 

  3. Priya S, Carlos VP. Fusarium infection after solid-organ transplantation. Clin Infect Dis. 2001;32:1237–40.

    Article  Google Scholar 

  4. Nucci M, Marr KA, Queiroz TF, Martins CA, Trabasso P, Costa S. Fusarium infection in hematopoietic stem cell transplant recipients. Clin Infect Dis. 2004;38:1237–42.

    Article  PubMed  Google Scholar 

  5. Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis. 2002;35:909–20.

    Article  PubMed  Google Scholar 

  6. Guarro J, Gené J. Opportunistic fusarial infections in humans. Eur J Clin Microbiol Infect Dis. 1995;14:741–54.

    Article  CAS  PubMed  Google Scholar 

  7. Nucci M, Anaissie E. Fusarium infections in immunocompromised patients. Clin Microbiol Rev. 2007;20:695–704.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Fleming RV, Walsh TJ, Anaissie EJ. Emerging and less common fungal pathogens. Infect Dis Clin N Am. 2002;16:915–33.

    Article  Google Scholar 

  9. Ferrer C, Alio J, Rodriguez A, Andreu M, Colom F. Endophthalmitis caused by Fusarium proliferatum. J Clin Microbiol. 2005;10:5372–5.

    Article  Google Scholar 

  10. Summerbell RC, Richardson SE, Kane J. Fusarium proliferatum as an agent of disseminated infection in an immunosuppressed patient. J Clin Microbiol. 1988;26:82–7.

    PubMed Central  CAS  PubMed  Google Scholar 

  11. Hattori N, Shirai A, Sugiura Y, Li W, Yokoyama K, Misawa Y, et al. Onychomycosis caused by Fusarium proliferatum. Br J Dermatol. 2005;153(3):647–9.

    Article  CAS  PubMed  Google Scholar 

  12. Neuburger S, Massenkeil G, Seibold M, Lutz C, Tamm I, Coutre P, Graf B, et al. Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation. Transpl Infect Dis. 2008;10:290–3.

    Article  CAS  PubMed  Google Scholar 

  13. Seyfarth F, Ziemer M, Sayer HG, Burmester A, Erhard M, Welker M, et al. The use of ITS DNA sequence analysis and MALDI-TOF mass spectrometry in diagnosing an infection with Fusarium proliferatum. Exp Dermatol. 2008;17:965–71.

    Article  CAS  PubMed  Google Scholar 

  14. Palmore TN, Shea YR, Childs RW, Sherry RM, Walsh TJ. Fusarium proliferatum soft tissue infection at the site of a puncture by a plant: recovery, isolation, and direct molecular identification. J Clin Microbiol. 2010;48:338–42.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Brasch J, Shimanovich I. Persistent fingernail onychomycosis caused by Fusarium proliferatum in a healthy woman. Mycoses. 2012;55:86–9.

    Article  CAS  PubMed  Google Scholar 

  16. Dananché C, Cassier P, Sautour M, Gautheron N, Wegrzyn J, Perraud M, et al. Fungaemia caused by Fusarium proliferatum in a patient without definite immunodeficiency. Mycopathologia. 2015;179:135–40.

    Article  PubMed  Google Scholar 

  17. Consigny S, Dhedin N, Datry A, Choquet S, Leblond V, Chosidow O. Successsful voriconazole treatment of disseminated Fusarium infection in an immunocompromised patient. Clin Infect Dis. 2003;37:311–3.

    Article  PubMed  Google Scholar 

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Acknowledgments

We strongly appreciate the help from Professor Weida Liu and Doctor Yiping Ge who work in Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, and carried out molecular identification tests of etiologic agent of the patient.

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Authors and Affiliations

  1. The Center for Medical Mycology, Department of Dermatology, Huashan Hospital, Fudan University, No 12, Middle Urumqi Road, Shanghai, 200040, People’s Republic of China

    Huilin Su, Qiangqiang Zhang, Li Li, Ying Zhao, Junhao Zhu & Min Zhu

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  1. Huilin Su
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  2. Qiangqiang Zhang
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  3. Li Li
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  4. Ying Zhao
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  5. Junhao Zhu
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  6. Min Zhu
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Correspondence to Min Zhu.

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Su, H., Zhang, Q., Li, L. et al. Urinary Tract Infection (UTI) Caused by Fusarium proliferatum in an Agranulocytosis Patient and a Review of Published Reports. Mycopathologia 181, 131–135 (2016). https://doi.org/10.1007/s11046-015-9937-7

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  • DOI: https://doi.org/10.1007/s11046-015-9937-7

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