Molecular Biology Reports

, Volume 41, Issue 2, pp 895–899

Association between BH3 interacting domain death agonist (BID) gene polymorphism and ossification of the posterior longitudinal ligament in Korean population

  • Jinmann Chon
  • Jang-Hyeok Hong
  • Jinsung Kim
  • Yoo Jin Han
  • Byoung Wook Lee
  • Soo-Cheol Kim
  • Dong Hwan Kim
  • Seung Don Yoo
  • Hee-Sang Kim
  • Dong Hwan Yun
Article

DOI: 10.1007/s11033-013-2933-4

Cite this article as:
Chon, J., Hong, JH., Kim, J. et al. Mol Biol Rep (2014) 41: 895. doi:10.1007/s11033-013-2933-4

Abstract

The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the BH3 interacting domain death agonist (BID) gene as a risk factor in Korean patients with ossification of the posterior longitudinal ligament (OPLL). To investigate the genetic association, two coding SNPs (rs8190315, Ser10Gly; rs2072392, Asp60Asp) of BID were genotyped in 157 OPLL patients and 209 control subjects. SNPStats, SNPAnalyzer Pro, Helixtree, and Haploview 4.2 programs were used for association analysis. Multiple logistic regression models (codominant, dominant, and recessive) were calculated for the odds ratios (ORs), 95 % confidence intervals (CIs), and corresponding P values. For multiple testing, Bonferroni correction was performed. After Bonferroni correction, genotype analysis of both rs8190315 and rs2072392 showed association between the OPLL group and the control group in the codominant model (P = 0.042, OR 1.86, 95 % CI 1.10–3.15). A complete linkage disequilibrium block was estimated between the two SNPs. Both of the G allele of rs8190315 and C allele of rs2072392 were strongly associated with an increased risk in the development of OPLL (P = 0.0052, OR 2.66, 95 % CI 1.51–4.68). These results suggest that BID is associated with OPLL, and both the G allele of a missense SNP (rs8190315, Ser10Gly) and C allele of a synonymous SNP (rs2072392, Asp60Asp) are risk factors for the development of OPLL in Korean population.

Keywords

BID Haplotype Linkage Disequilibrium Polymorphism Ossification of the posterior longitudinal ligament 

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Jinmann Chon
    • 1
  • Jang-Hyeok Hong
    • 1
  • Jinsung Kim
    • 1
  • Yoo Jin Han
    • 1
  • Byoung Wook Lee
    • 2
  • Soo-Cheol Kim
    • 3
  • Dong Hwan Kim
    • 1
  • Seung Don Yoo
    • 1
  • Hee-Sang Kim
    • 1
  • Dong Hwan Yun
    • 1
  1. 1.Department of Physical Medicine & Rehabilitation, College of MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of Biochemistry and Molecular BiologyKyung Hee UniversitySeoulRepublic of Korea
  3. 3.Department of Thoracic and Cardiovascular Surgery, College of MedicineKyung Hee UniversitySeoulRepublic of Korea