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Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China

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Abstract

Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and mortality, influenced by both environmental factor and genetic factor. ADAM33 gene was found to be associated with asthma, declined lung function and COPD. The purpose of the study was to test whether SNPs in ADAM33 were associated with COPD in Tibetan population of China. Polymerase chain reaction-restriction fragment length polymorphism was carried out to genotype the eight SNPs (V4, T2, T1, S2, S1, Q-1 and F + 1) of ADAM33 on 240 COPD patients and 221 healthy individuals. Four SNPs (V4, T2, T1 and S1) and four haplotypes (H2 CGAAGAGC, H5 GAGAGAGC, H9 GAAAGAGC and H6 CGGGGAGC of ADAM33 gene were associated with COPD significantly (defined as P < 0.05). The results indicate that there is an association between ADAM33 polymorphisms and COPD in Tibetan population of China.

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Acknowledgments

We greatly acknowledge the numerous donors for making this work possible.

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Authors and Affiliations

  1. Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China

    Jinling Xiao, Xinyan Wang, Dongju Su, Yongxia Bao & Fuzhen Lv

  2. Department of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China

    Jianyu Han

  3. Department of Respiratory, The Second People’s Hospital of Tibet, Lasa, Tibet, China

    Demi Hua

Authors
  1. Jinling Xiao
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  2. Jianyu Han
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  3. Xinyan Wang
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  4. Demi Hua
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  5. Dongju Su
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  6. Yongxia Bao
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  7. Fuzhen Lv
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Corresponding author

Correspondence to Fuzhen Lv.

Additional information

Jinling Xiao and Jianyu Han contributed equally to this work.

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Xiao, J., Han, J., Wang, X. et al. Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China. Mol Biol Rep 38, 4941–4945 (2011). https://doi.org/10.1007/s11033-010-0637-6

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  • DOI: https://doi.org/10.1007/s11033-010-0637-6

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