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One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines

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Abstract

A green one-pot four-component strategy has been developed for the synthesis of [1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives using an amine, 2,2,6-trimethyl-4H-1,3-dioxin-4-one, an aldehyde, and 3-amino-1,2,4-triazole in the presence of a catalytic amount of p-toluenesulfonic acid in water within 4–6 h.

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Acknowledgments

We gratefully acknowledge financial support from the Iran National Elites Foundation (INEF) and Research Council of Shahid Beheshti University.

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Authors and Affiliations

  1. Faculty of Chemistry, Shahid Beheshti University, G. C, P. O. Box 19396-4716, Tehran, Iran

    Ahmad Shaabani, Mozhdeh Seyyedhamzeh, Nasim Ganji & Mona Hamidzad Sangachin

  2. Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 3 Research Link, Singapore, 117602, Singapore

    Mahsa Armaghan

Authors
  1. Ahmad Shaabani
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  2. Mozhdeh Seyyedhamzeh
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  3. Nasim Ganji
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  4. Mona Hamidzad Sangachin
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  5. Mahsa Armaghan
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Corresponding author

Correspondence to Ahmad Shaabani.

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Shaabani, A., Seyyedhamzeh, M., Ganji, N. et al. One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines. Mol Divers 19, 709–715 (2015). https://doi.org/10.1007/s11030-015-9604-4

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