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A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno[3,2-c]pyridines

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Abstract

A facile and efficient synthesis of a library of novel chromeno[3,2-\(c\)]pyridines has been achieved from the reaction of various 3,5-((\(E\))-arylidene)-1-alkylpiperidin-4-ones and cyclic 1,3-diketones. The reaction presumably occurred via tandem Michael addition–intramolecular \(O\)-cyclization–elimination sequence in a single operation.

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Acknowledgments

RRK thanks the University Grants Commission, New Delhi for funds through Major Research Project F. No. 42-242/2013 (SR) and Department of Science and Technology, New Delhi for funds under (i) IRHPA program for the high resolution NMR facility in the Department and (ii) PURSE program. RVS thanks the University Grants Commission, New Delhi for research fellowship.

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  1. Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625 021, Tamil Nadu, India

    Remani Vasudevan Sumesh, Akilan Malathi & Raju Ranjith Kumar

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  1. Remani Vasudevan Sumesh
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Correspondence to Raju Ranjith Kumar.

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Sumesh, R.V., Malathi, A. & Ranjith Kumar, R. A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno[3,2-c]pyridines. Mol Divers 19, 233–249 (2015). https://doi.org/10.1007/s11030-015-9576-4

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