Abstract
We reported a 53-year-old with late-onset mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) accompanied by aneurysm and large vessel dilations. Most studies have focused on microangiopathy causing stroke-like episodes. We report a case to describe large vessel involvement in clinical considerations, and possible mechanisms of aneurysm formation. We recommended regular angiographic examination for patients with MELAS.
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Abbreviations
- MELAS:
-
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes
- NAA:
-
N-acetyl aspartate
- NO:
-
nitric oxide
- eNOS:
-
endothelial nitric oxide synthase
- UIA:
-
unruptured intracranial aneurysm
- DSA:
-
digital subtraction angiography
- IA:
-
intracranial aneurysm
- IL:
-
interleukin
- DAMPs:
-
damage associated molecular patterns
- COX:
-
cytochrome c oxidase
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Zhu, K., Li, S., Chen, H. et al. Late onset MELAS with m.3243A > G mutation and its association with aneurysm formation. Metab Brain Dis 32, 1069–1072 (2017). https://doi.org/10.1007/s11011-017-9989-0
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DOI: https://doi.org/10.1007/s11011-017-9989-0