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Increased brain iron deposition is a risk factor for brain atrophy in patients with haemodialysis: a combined study of quantitative susceptibility mapping and whole brain volume analysis

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Abstract

To explore the correlation between increased brain iron deposition and brain atrophy in patients with haemodialysis and their correlation with clinical biomarkers and neuropsychological test. Forty two patients with haemodialysis and forty one age- and gender-matched healthy controls were recruited in this prospective study. 3D whole brain high resolution T1WI and susceptibility weighted imaging were scanned on a 3 T MRI system. The brain volume was analyzed using voxel-based morphometry (VBM) in patients and to compare with that of healthy controls. Quantitative susceptibility mapping was used to measure and compare the susceptibility of different structures between patients and healthy controls. Correlation analysis was used to investigate the relationship between the brain volume, iron deposition and neuropsychological scores. Stepwise multiple regression analysis was used to explore the effect of clinical biomarkers on the brain volumes in patients. Compared with healthy controls, patients with haemodialysis showed decreased volume of bilateral putamen and left insular lobe (All P < 0.05). Susceptibilities of bilateral caudate head, putamen, substantia nigra, red nucleus and dentate nucleus were significantly higher (All P < 0.05). The increased brain iron deposition is negatively correlated with the decreased volume of bilateral putamen (P < 0.01). Neuropsychological scores positively correlated with decreased volume of left insular lobe (P < 0.05). Dialysis duration was negatively associated with decreased volume of bilateral putamen (P < 0.05). Our study indicated increased brain iron deposition and dialysis duration was risk factors for brain atrophy in patients with haemodialysis. The decreased gray matter volume of the left insular lobe was correlated with neurocognitive impairment.

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Acknowledgments

Supported by a grant from China Postdoctoral Science Foundation (grant No. 201150 M1573 to S. X.).

Conflict of interest

The authors disclose no conflicts.

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Authors and Affiliations

  1. Department of Medical Imaging, Tianjin First Central Hospital, Tianjin, 300192, China

    Chao Chai, Mengjie Zhang, Miaomiao Long, Yu Guo, Shuo Yan, Wen Shen & Shuang Xia

  2. Department of Haemodialysis, Tianjin First Central Hospital, Tianjin, 300192, China

    Zhiqiang Chu, Tong Wang & Lijun Wang

  3. Department of Radiology, Wayne State University, Detroit, Michigan, USA

    E. Mark Haacke

Authors
  1. Chao Chai
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  2. Mengjie Zhang
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  3. Miaomiao Long
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  4. Zhiqiang Chu
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  5. Tong Wang
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  6. Lijun Wang
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  7. Yu Guo
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  8. Shuo Yan
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  9. E. Mark Haacke
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  10. Wen Shen
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  11. Shuang Xia
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Corresponding authors

Correspondence to Wen Shen or Shuang Xia.

Additional information

Chao Chai and Mengjie Zhang equally contribute to the paper in the designing, collecting the patients and writing.

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Chai, C., Zhang, M., Long, M. et al. Increased brain iron deposition is a risk factor for brain atrophy in patients with haemodialysis: a combined study of quantitative susceptibility mapping and whole brain volume analysis. Metab Brain Dis 30, 1009–1016 (2015). https://doi.org/10.1007/s11011-015-9664-2

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  • DOI: https://doi.org/10.1007/s11011-015-9664-2

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