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Synthesis and microcalorimetric determination of the bioactivities of a new Schiff base and its bismuth(III) complex derived from o-vanillin and 2,6-pyridinediamine

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Abstract

In this work, a new Schiff base [N,N′-bis(2-hydroxy-3-methoxyphenylmethylidene)-2,6-pyridinediamine, C21H19N3O4] and its bismuth(III) complex [Bi(C21H17N3O4)]Cl·2H2O were synthesized with o-vanillin and 2,6-pyridinediamine in ethanol and THF solvent, respectively. The compositions and structures of the two synthetic compounds were characterized by elemental analysis, chemical analysis, spectrum analysis (including MS, FT-IR, NMR, and UV–Vis), and thermogravimetric analysis. The thermogenic curves for the growth metabolism of Helicobacter pylori (H. pylori) and Schizosaccharomyces pombe (S. pombe) treated by different concentrations of the two synthetic compounds were determined by isothermal heat conduction microcalorimetry at 37.00 and 32.00 °C, respectively. Based on the thermogenic curves, some important thermokinetic parameters including the microbial growth rate constant (k), inhibition ratio (I), and half inhibition concentration (IC50) were calculated. The obtained results revealed that the Schiff base stimulated the growth of H. pylori, while the complex inhibited its growth. By contrast, both the Schiff base and the complex inhibited the growth of S. pombe, but the inhibitory effect of the complex was stronger than that of the Schiff base.

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Acknowledgments

The authors would like to acknowledge the financial supports from the National Natural Science Foundation of China (Grant Nos. 21273190 and 20973145), the Science and Technology Department Foundation of Hunan Province (Grant No. 2014TT2026), and the Educational Committee Foundation of Hunan Province (Grant Nos. 15C1272, 15A175, and 14A134). Prof. Qiang-Guo Li (E-mail: liqiangguo@163.com) is the chief-director of these fund projects.

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Authors and Affiliations

  1. Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds and Applications, College of Chemistry Biology and Environmental Engineering, Xiangnan University, Chenzhou, 423043, Hunan Province, People’s Republic of China

    Xu Li, Chuan-Hua Li, Jian-Hong Jiang, De-Liang Wei, Li-Juan Ye, Ji-Lin Hu, Sheng-Xiong Xiao, Xia Li, Hui Zhang & Qiang-Guo Li

  2. College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei Province, People’s Republic of China

    Hui-Wen Gu

  3. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, Hunan Province, People’s Republic of China

    Dong-Cai Guo

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  1. Xu Li
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Li, X., Li, CH., Jiang, JH. et al. Synthesis and microcalorimetric determination of the bioactivities of a new Schiff base and its bismuth(III) complex derived from o-vanillin and 2,6-pyridinediamine. J Therm Anal Calorim 127, 1767–1776 (2017). https://doi.org/10.1007/s10973-016-5892-x

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