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Stability and dehydration kinetics of the monohydrate racemic tartaric acid

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Abstract

Racemic tartaric acid (race-TA) exists in the solid state as a monohydrate and an anhydrous. There is a large difference in their bioavailability and product performance. In this paper, the stability of monohydrate race-TA was investigated. The results show that water activity is the major factor determining the stability of race-TA, monohydrate or anhydrous, which crystallizes from the mixed solvent at certain temperature. Meanwhile, the effect of temperature on the stability of monohydrate race-TA was studied using DSC, which is important to control the stability of monohydrate race-TA during drying and storage. Finally, the dehydration kinetics of monohydrate race-TA was investigated in nitrogen purge using TG–DSC. Based on the result, the kinetic parameters (activation energy and pre-exponential factor) and the most probable kinetic model that gives the best description of the dehydration process for monohydrate race-TA are obtained.

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Abbreviations

a w :

Water activity

T :

Temperature °C

K h :

Equilibrium constant

x w :

Water content

E :

Activation energy kJ mol−1

A :

Pre-exponential s−1

α :

Conversion rate %

β :

Heating rate °C min−1

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Authors and Affiliations

  1. Dagang Oilfield Company, China National Petroleum Corporation, Tianjin, 300280, China

    Xiaofang Wang & Guoqiang Zhu

  2. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    Xiaofang Wang, Leping Dang & Hongyuan Wei

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  1. Xiaofang Wang
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  2. Leping Dang
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  3. Guoqiang Zhu
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  4. Hongyuan Wei
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Correspondence to Hongyuan Wei.

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Wang, X., Dang, L., Zhu, G. et al. Stability and dehydration kinetics of the monohydrate racemic tartaric acid. J Therm Anal Calorim 123, 1919–1926 (2016). https://doi.org/10.1007/s10973-015-4699-5

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  • DOI: https://doi.org/10.1007/s10973-015-4699-5

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