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One-pot synthesis of polyvinyl alcohol/silica composite microspheres in a surfactant-free system for biomedical applications

  • Brief Communication: Sol-gel, hybrids and solution chemistries
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Abstract

A one-pot synthesis process was developed to prepare polyvinyl alcohol/silica (PVA/SiO2) composite microspheres. Uniform PVA/SiO2 hybrid sols were firstly obtained by in situ hydrolysis of tetraethyl orthosilicate (TEOS) in the PVA solution and then formulated into microspheres in a surfactant-free oil phase. The resultant PVA/SiO2 composite microspheres exhibited a regular spherical shape, a high dispersity and a homogenous microstructure. Their average particle diameter was determined as about 58.2 μm. The inorganic phase of the composite microspheres was identified as amorphous SiO2 with a condensation degree of about 62.4 %, and its actual content was in close agreement with the theoretical value. Moreover, the PVA/SiO2 composite microspheres were covered by apatite clusters after being soaked in simulated body fluid (SBF), indicating their good in vitro bioactivity.

Graphical Abstract

The bioactive PVA/SiO2 composite microspheres were fabricated via a sol–gel combined with surfactant-free emulsification technique. Amphorous SiO2 was uniformly distributed in the PVA matrix, producing composite microspheres with a good spherical form, a high dispersity and an average particle diameter of about 58.2 μm.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (No. 51303207), the Natural Science Foundation of Jiangsu Province of China (No. BK20130173) and the Fundamental Research Funds for the Central Universities (No. 2013QNA06).

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Authors and Affiliations

  1. School of Materials Science and Engineering, China University of Mining and Technology, Xuzhou, 221116, China

    Feng-Wu Chen, Shu-Hua Teng, Shu-Hui Xia, Peng Wang & Guo-Qing Pan

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  1. Feng-Wu Chen
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  2. Shu-Hua Teng
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  3. Shu-Hui Xia
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  4. Peng Wang
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  5. Guo-Qing Pan
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Correspondence to Shu-Hua Teng or Peng Wang.

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Chen, FW., Teng, SH., Xia, SH. et al. One-pot synthesis of polyvinyl alcohol/silica composite microspheres in a surfactant-free system for biomedical applications. J Sol-Gel Sci Technol 79, 525–529 (2016). https://doi.org/10.1007/s10971-016-4118-9

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  • DOI: https://doi.org/10.1007/s10971-016-4118-9

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