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Assessing environmental chemical uptake in fetal brain in utero: A preliminary PET/CT study

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Summary

Exposure to several environmental chemicals in utero is associated with subtle deleterious effects in cognitive, motor and behavioral functions. In order to assess in utero exposure to possible neurotoxins, fetal brain uptake of an exogenous compound given to a pregnant rhesus macaque was investigated using PET/CT imaging. CT clearly delineated the fetus which allowed the time course of the PET tracer in the fetal brain and other organs to be monitored. This study demonstrates the feasibility of quantifying the absolute fetal uptake of chemicals given systemically to the mother.

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Authors and Affiliations

  1. Department of Medical Physics, University of Wisconsin Medical School, Madison, WI, USA

    O. T. DeJesus

  2. Department of Medical Physics, University of Wisconsin Medical School, Madison, WI, USA

    L. G. Flores

  3. Keck Imaging Laboratory, Waisman Center, University of Wisconsin, Madison, WI, USA

    A. K. Converse

  4. Department of Medical Physics, University of Wisconsin Medical School, Madison, WI, USA

    R. M. Bartlett

  5. Department of Medical Physics, University of Wisconsin Medical School, Madison, WI, USA

    D. Murali

  6. Department of Medical Physics, University of Wisconsin Medical School, Madison, WI, USA

    R. Jeraj

  7. Keck Imaging Laboratory, Waisman Center, University of Wisconsin, Madison, WI, USA

    T. R. Oakes

  8. Department of Medical Physics, University of Wisconsin Medical School, Madison, WI, USA

    R. J. Nickles

  9. PET Clinic, University of Wisconsin Hospitals and Clinics, Madison, WI, USA

    C. J. Jaskowiak

Authors
  1. O. T. DeJesus
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  2. L. G. Flores
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  3. A. K. Converse
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  4. R. M. Bartlett
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  5. D. Murali
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  6. R. Jeraj
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  7. T. R. Oakes
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  8. R. J. Nickles
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  9. C. J. Jaskowiak
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DeJesus, O., Flores, L., Converse, A. et al. Assessing environmental chemical uptake in fetal brain in utero: A preliminary PET/CT study. J Radioanal Nucl Chem 269, 561–564 (2006). https://doi.org/10.1007/s10967-006-0265-8

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  • DOI: https://doi.org/10.1007/s10967-006-0265-8

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