Abstract
The biomaterials science has advanced in a high speed with global science and technology development during the recent decades, which experts predict to be more obvious in the near future with a more significant position for medicine and health care. Although the three traditional subjects, such as medical science, materials science and biology that act as a scaffold to support the structure of biomaterials science, are still essential for the research and education of biomaterials, other subjects, such as mechanical engineering, mechanics, computer science, automatic science, nanotechnology, and Bio-MEMS, are playing more and more important roles in the modern biomaterials science development. Thus, the research and education of modern biomaterials science should require a logical integration of the interdisciplinary science and technology, which not only concerns medical science, materials science and biology, but also includes other subjects that have been stated above. This article focuses on multidisciplinary nature of biomaterials, the awareness of which is currently lacking in the education at undergraduate stage. In order to meet this educational challenge, we presented a multidisciplinary course that referred to not only traditional sciences, but also frontier sciences and lasted for a whole academic year for senior biomaterials undergraduate students with principles of a better understanding of the modern biomaterials science and meeting the requirements of the future development in this area. The course has been shown to gain the recognition of the participants by questionaries and specific “before and after” comments and has also gained high recognition and persistent supports from our university. The idea of this course might be also fit for the education and construction of some other disciplines.
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References
Agarwala MK, Jamalabad VR, Langrana NA, Safari A, Whalen PJ, Danforth SC (1996) Structural quality of parts processed by fused deposition. Rapid Prototyp J 2(4):4–19
Ang TH, Sultana FSA, Hutmacher DW, Wong YS, Fuh JYH, Mo XM, Loh HT, Burdet E, Teoh SH (2002) Fabrication of 3D chitosan-hydroxyapatite scaffolds using a robotic dispensing system. Mater Sci Eng, C 20(1–2):35–42
Arcand BY, Bhatti PT, Butala NV, Wang J, Friedrich CR, Wise KD (2004) Active positioning device for a perimodiolar cochlear electrode array. Microsyst Technol 10(6–7):478–483
Binder K (1995) Monte Carlo and Molecular Dynamics Simulations in Polymer Science. Oxford University Press, New York
Buzsáki G (2004) Large-scale recording of neuronal ensembles. Nat Neurosci 7(5):446–451
Chua CK, Leong KF, Lim CS (1997) Rapid prototyping: principles and applications in manufacturing. Wiley, New York, p 350
Cima LG, Vacanti JP, Vancanti C, Ingber D, Mooney D, Langer R (1991) Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng 113(2):143–151
Crubzy E, Murail P, Girard L, Bernadou JP (1998) False teeth of the Roman world. Nature 391(6662):29
Folch A (2013) Introduction to bio-MEMS. CRC Press, Boca Raton
Freed LE, Vunjak G, Biron RJ, Eagles DB, Lesnoy DC, Barlow SK, Langer R (1994) Biodegradable polymer scaffolds for tissue engineering. Nature Biotechnol 12:689–693
Gabel M (2010) The design science/global solutions lab: interdisciplinary problem/project-based research and learning. ASEE American Society For Engineering Education Spring 2010 Middle-Atlantic section conference
Gardiner KM (2012) Virtual and collaborative project-based learning. ASEE Northeast section conference
Healy KE, Rezania A, Stile RA (2006) Designing biomaterials to direct biological responses. Ann N Y Acad Sci 875(1):24–35
Hochberg LR, Serruya MD, Friehs GM, Mukand JA, Saleh M, Caplan AH, Branner A, Chen D, Penn RD, John P (2006) Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442(7099):164–171
Hosokawa H, Robinson J (2010) Alpha robotics: a multi-disciplinary approach to teaching engineering concepts to K-2 students. In: ASEE proceeding of the 2010 American Society for Engineering Education annual conference & exposition
Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21(24):2529–2543
Kanter DE, Reiser BJ, Troy JB (2001) A systems physiology instructional environment for biomedical engineers: a design grounded in the learning sciences. ASEE proceeding of the 2001 American Society for Engineering Education annual conference & exposition
Khan MS, Rehman S, Ali MA, Sultan B, Sultan S (2008) Infection in orthopedic implant surgery, its risk factors and outcome. J Ayub Med Coll Abbottabad 20(1):23–25
Kim DH, Lu N, Ma R, Kim YS, Kim RH, Wang S, Wu J, Won SM, Tao H, Islam A, Yu KJ et al (2011) Epidermal electronics. Science 333(6044):838–843
King RH, Parker TE, Grover TP, Gosink JP, Middleton NT (1999) A multidisciplinary engineering laboratory course. J Eng Educ 88(3):311–316
Li XM, Feng QL, Liu XH, Dong W, Cui FZ (2006) Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model. Biomaterials 27(9):1917–1923
Li XM, Van Blitterswijk CA, Feng QL, Cui FZ, Watari F (2008) The effect of calcium phosphate microstructure on bone-related cells in vitro. Biomaterials 29(23):3306–3316
Li XM, Gao H, Uo M, Sato Y, Akasaka T, Feng QL, Cui FZ, Liu XH, Watari F (2009a) Effect of carbon nanotubes on cellular functions in vitro. J Biomed Mater Res A 91A(1):132–139
Li XM, Gao H, Uo M, Sato Y, Akasaka T, Abe S, Feng QL, Cui FZ, Watari F (2009b) Maturation of osteoblast-like SaoS2 induced by carbon nanotubes. Biomed Mater 4(1):015005
Li XM, Fan YB, Watari F (2010) Current investigations into carbon nanotubes for biomedical application. Biomed Mater 5(2):22001. doi:10.1088/1748-6041/5/2/022001
Li XM, Liu HF, Niu XF, Yu B, Fan YB, Feng QL, Cui FZ, Watari F (2011) Osteogenic differentiation of human adipose-derived stem cells induced by osteoinductive calcium phosphate ceramics. J Biomed Mater Res B Appl Biomater 97B(1):10–19
Li XM, Liu HF, Niu XF, Yu B, Fan YB, Feng QL, Cui FZ, Watari F (2012) The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo. Biomaterials 33(19):4818–4827
Li XM, Wang L, Fan YB, Feng QL, Cui FZ, Watari F (2013) Nanostructured scaffolds for bone tissue engineering. J Biomed Mater Res A 101A(8):2424–2435
Li XM, Huang Y, Zheng LS, Liu HF, Niu XF, Huang J, Zhao F, Fan YB (2014a) Effect of substrate stiffness on the functions of rat bone marrow and adipose tissue derived mesenchymal stem cells in vitro. J Biomed Mater Res A 102(4):1092–1101
Li XM, Yang Y, Fan YB, Feng QL, Cui FZ, Watari F (2014b) Biocomposites reinforced by fibers or tubes, as scaffolds for tissue engineering or regenerative medicine. J Biomed Mater Res A 102(5):1580–1594
Mikos AG, Temenoff JS (2000) Formation of highly porous biodegradable scaffolds for tissue engineering. EJB Electron J Biotechnol 3(2):23–24
Samanta B, Nataraj C (2008) Automated diagnosis of cardiac state in healthcare systems using computational intelligence. Int J Services Oper Inform 3(2):162–177
Samanta B, Bird GL, Kuijpers M, Zimmerman RA, Jarvik GP, Wernovsky G, Clancy RR, Licht DJ, Gaynor JW, Nataraj C (2009a) Prediction of periventricular leukomalacia—Part I: selection of hemodynamic features using logistic regression and decision tree algorithms. Artif Intell Med 46(3):201–215
Samanta B, Bird GL, Kuijpers M, Zimmerman RA, Jarvik GP, Wernovsky G, Clancy RR, Licht DJ, Gaynor JW, Nataraj C (2009b) Prediction of periventricular leukomalacia—Part II: selection of hemodynamic features using computational intelligence. Artif Intell Med 46(3):217–231
Schierholz JM, Beuth J (2001) Implant infections: a haven for opportunistic bacteria. J Hosp Infect 49(2):87–93
Stevens MM, George JH (2005) Exploring and engineering the cell surface interface. Science 310(5751):1135–1138
Tjaden B (2007) A multidisciplinary course in computational biology. J Comput Sci Coll 22(6):80–87
Tsapis N, Bennett D, Jackson B, Weitz DA, Edwards DA (2002) Trojan particles: large porous carriers of nanoparticles for drug delivery. Proc Natl Acad Sci USA 99(19):12001–12005
Viventi J, Kim DH, Moss JD, Kim YS, Blanco JA, Annetta N, Hicks A, Xiao JL, Huang YG, Callans DJ, Rogers JA, LITT B (2010) A conformal, bio-interfaced class of silicon electronics for mapping cardiac electrophysiology. Sci Transl Med 2(24):24ra22. doi:10.1126/scitranslmed.3000738
Acknowledgments
The authors acknowledge the financial supports from the National Natural Science Foundation of China (No. 31370959), Beijing Natural Science Foundation (No. 7142094), Fok Ying Tung Education Foundation (No. 141039), Program for New Century Excellent Talents (NCET) in University from Ministry of Education of China, State Key Laboratory of New Ceramic and Fine Processing (Tsinghua University), International Joint Research Center of Aerospace Biotechnology and Medical Engineering, Ministry of Science and Technology of China, and the 111 Project (No. B13003).
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Feng Zhao is co-first author of this article.
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Li, X., Zhao, F., Pu, F. et al. A Multidisciplined Teaching Reform of Biomaterials Course for Undergraduate Students. J Sci Educ Technol 24, 735–746 (2015). https://doi.org/10.1007/s10956-015-9559-3
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DOI: https://doi.org/10.1007/s10956-015-9559-3