Skip to main content
Log in

Collective Dynamics on a Two-Lane Asymmetrically Coupled TASEP with Mutually Interactive Langmuir Kinetics

  • Published:
Journal of Statistical Physics Aims and scope Submit manuscript

Abstract

Motivated by the recent experimental observations on clustering of motor proteins on microtubule filament, we study an open system of two parallel totally asymmetric simple exclusion processes under asymmetric coupling conditions, which incorporates the mutual interaction with the surrounding environment through Langmuir Kinetics (LK) in both the lanes. In the modified LK, the attachment and detachment rates depends on the configuration of nearest neighboring sites. We analyse the model within the framework of continuum mean-field theory and the phase diagrams along with density profiles are obtained using boundary layer analysis. The effect of mutual interactions on the phase diagram for two different situations of attachment and detachment (LK) rates is discussed. Under the symmetric LK dynamics, the topological structure of the phase diagram remains similar to the one in without mutual interaction; while for the antisymmetric case, after a certain critical value of attractive/repulsive mutual attraction, significant changes are found in the qualitative nature of phase diagram. Moreover, it is shown that the type of mutual interaction affects the dynamic properties of motor proteins. The theoretical findings are examined by extensive Monte-Carlo simulations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Celis-Garza, D., Teimouri, H., Kolomeisky, A.B.: Correlations and symmetry of interactions influence collective dynamics of molecular motors. J. Stat. Mech. 2015(4), P04013 (2015)

    Article  Google Scholar 

  2. Chandel, S., Chaudhuri, A., Muhuri, S.: Collective transport of weakly interacting molecular motors with Langmuir kinetics. EPL (Europhys. Lett.) 110(1), 18002 (2015)

    Article  ADS  Google Scholar 

  3. Chowdhury, D.: Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist’s perspective. Phys. Rep. 529(1), 1–197 (2013)

    Article  ADS  Google Scholar 

  4. Chowdhury, D., Santen, L., Schadschneider, A.: Statistical physics of vehicular traffic and some related systems. Phys. Rep. 329(4), 199–329 (2000)

    Article  ADS  MathSciNet  Google Scholar 

  5. Derrida, B., Evans, M., Hakim, V., Pasquier, V.: Exact solution of a 1D asymmetric exclusion model using a matrix formulation. J. Phys. A 26(7), 1493 (1993)

    Article  ADS  MathSciNet  MATH  Google Scholar 

  6. Dhiman, I., Gupta, A.K.: Effect of coupling strength on a two-lane partially asymmetric coupled totally asymmetric simple exclusion process with Langmuir kinetics. Phys. Rev. E 90(1), 012114 (2014)

    Article  ADS  Google Scholar 

  7. Evans, M., Juhasz, R., Santen, L.: Shock formation in an exclusion process with creation and annihilation. Phys. Rev. E 68(2), 026117 (2003)

    Article  ADS  Google Scholar 

  8. Frey, E., Parmeggiani, A., Franosch, T.: Collective phenomena in intracellular processes. Genome Inform. 15(1), 46–55 (2004)

    Google Scholar 

  9. Gupta, A.K., Dhiman, I.: Asymmetric coupling in two-lane simple exclusion processes with Langmuir kinetics: phase diagrams and boundary layers. Phys. Rev. E 89(2), 022131 (2014)

    Article  ADS  Google Scholar 

  10. Howard, J.: Mechanics of Motor Proteins and the Cytoskeleton. Sinauer Associates, Sunderland (2001)

    Google Scholar 

  11. Howard, J., Clark, R.: Mechanics of motor proteins and the cytoskeleton. Appl. Mech. Rev. 55, 39 (2002)

    Article  Google Scholar 

  12. Jiang, R., Hu, M.B., Wu, Y.H., Wu, Q.S.: Weak and strong coupling in a two-lane asymmetric exclusion process. Phys. Rev. E 77(4), 041128 (2008)

    Article  ADS  MathSciNet  Google Scholar 

  13. Jiang, R., Wang, R., Wu, Q.S.: Two-lane totally asymmetric exclusion processes with particle creation and annihilation. Physica A 375(1), 247–256 (2007)

    Article  ADS  Google Scholar 

  14. Katz, S., Lebowitz, J.L., Spohn, H.: Nonequilibrium steady states of stochastic lattice gas models of fast ionic conductors. J. Stat. Phys. 34(3–4), 497–537 (1984)

    Article  ADS  MathSciNet  Google Scholar 

  15. Kolomeisky, A.B.: Motor proteins and molecular motors: how to operate machines at the nanoscale. J. Phys. 25(46), 463101 (2013)

    MathSciNet  Google Scholar 

  16. Kolomeisky, A.B., Schütz, G.M., Kolomeisky, E.B., Straley, J.P.: Phase diagram of one-dimensional driven lattice gases with open boundaries. J. Phys. A 31(33), 6911 (1998)

    Article  ADS  MATH  Google Scholar 

  17. Krug, J.: Boundary-induced phase transitions in driven diffusive systems. Phys. Rev. Lett. 67(14), 1882 (1991)

    Article  ADS  MathSciNet  Google Scholar 

  18. Levine, E., Willmann, R.: Spontaneous symmetry breaking in a non-conserving two-species driven model. J. Phys. A 37(10), 3333 (2004)

    Article  ADS  MathSciNet  MATH  Google Scholar 

  19. MacDonald, C.T., Gibbs, J.H., Pipkin, A.C.: Kinetics of biopolymerization on nucleic acid templates. Biopolymers 6(1), 1–25 (1968)

    Article  Google Scholar 

  20. Mirin, N., Kolomeisky, A.B.: Effect of detachments in asymmetric simple exclusion processes. J. Stat. Phys. 110(3–6), 811–823 (2003)

    Article  MathSciNet  MATH  Google Scholar 

  21. Mukherji, S., Mishra, V.: Bulk and surface transitions in asymmetric simple exclusion process: impact on boundary layers. Phys. Rev. E 74(1), 011116 (2006)

    Article  ADS  MathSciNet  Google Scholar 

  22. Neri, I., Kern, N., Parmeggiani, A.: Exclusion processes on networks as models for cytoskeletal transport. New J. Phys. 15(8), 085005 (2013)

    Article  ADS  Google Scholar 

  23. Parmeggiani, A., Franosch, T., Frey, E.: Phase coexistence in driven one-dimensional transport. Phys. Rev. Lett. 90(8), 086601 (2003)

    Article  ADS  Google Scholar 

  24. Parmeggiani, A., Franosch, T., Frey, E.: Totally asymmetric simple exclusion process with Langmuir kinetics. Phys. Rev. E 70(4), 046101 (2004)

    Article  ADS  MathSciNet  Google Scholar 

  25. Popkov, V., Rákos, A., Willmann, R.D., Kolomeisky, A.B., Schütz, G.M.: Localization of shocks in driven diffusive systems without particle number conservation. Phys. Rev. E 67(6), 066117 (2003)

    Article  ADS  Google Scholar 

  26. Popkov, V., Schütz, G.M.: Steady-state selection in driven diffusive systems with open boundaries. EPL (Europhys. Lett.) 48(3), 257 (1999)

    Article  ADS  Google Scholar 

  27. Privman, V.: Nonequilibrium Statistical Mechanics in One Dimension. Cambridge University Press, Cambridge (2005)

    MATH  Google Scholar 

  28. Pronina, E., Kolomeisky, A.B.: Two-channel totally asymmetric simple exclusion processes. J. Phys. A 37(42), 9907 (2004)

    Article  ADS  MathSciNet  MATH  Google Scholar 

  29. Pronina, E., Kolomeisky, A.B.: Asymmetric coupling in two-channel simple exclusion processes. Physica A 372(1), 12–21 (2006)

    Article  ADS  MathSciNet  MATH  Google Scholar 

  30. Roos, W.H., Campàs, O., Montel, F., Woehlke, G., Spatz, J.P., Bassereau, P., Cappello, G.: Dynamic kinesin-1 clustering on microtubules due to mutually attractive interactions. Phys. Biol. 5(4), 046004 (2008)

    Article  ADS  Google Scholar 

  31. Schütz, G., Domany, E.: Phase transitions in an exactly soluble one-dimensional exclusion process. J. Stat. Phys. 72(1–2), 277–296 (1993)

    Article  ADS  MATH  Google Scholar 

  32. Seitz, A., Surrey, T.: Processive movement of single kinesins on crowded microtubules visualized using quantum dots. EMBO J. 25(2), 267–277 (2006)

    Article  Google Scholar 

  33. Sopasakis, A., Katsoulakis, M.A.: Stochastic modeling and simulation of traffic flow: asymmetric single exclusion process with Arrhenius look-ahead dynamics. SIAM J. Appl. Math. 66(3), 921–944 (2006)

    Article  MathSciNet  MATH  Google Scholar 

  34. Teimouri, H., Kolomeisky, A.B., Mehrabiani, K.: Theoretical analysis of dynamic processes for interacting molecular motors. J. Phys. A 48(6), 065001 (2015)

    Article  ADS  MathSciNet  MATH  Google Scholar 

  35. Toroczkai, Z., Zia, R.: A model for electrophoresis of polymers with impurities: exact distribution for a steady state. Phys. Lett. A 217(2), 97–103 (1996)

    Article  ADS  Google Scholar 

  36. Vilfan, A., Frey, E., Schwabl, F., Thormählen, M., Song, Y.H., Mandelkow, E.: Dynamics and cooperativity of microtubule decoration by the motor protein kinesin. J. Mol. Biol. 312(5), 1011–1026 (2001)

    Article  Google Scholar 

  37. Vuijk, H., Rens, R., Vahabi, M., MacKintosh, F., Sharma, A.: Driven diffusive systems with mutually interactive Langmuir kinetics. Phys. Rev. E 91(3), 032143 (2015)

    Article  ADS  Google Scholar 

  38. Wang, R., Jiang, R., Liu, M., Liu, J., Wu, Q.S.: Effects of Langmuir kinetics on two-lane totally asymmetric exclusion processes of molecular motor traffic. Int. J. Mod. Phys. C 18(09), 1483–1496 (2007)

    Article  ADS  MATH  Google Scholar 

Download references

Acknowledgments

The author gratefully acknowledges the financial support from the Department of Science and Technology (DST), Government of India.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Arvind Kumar Gupta.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gupta, A.K. Collective Dynamics on a Two-Lane Asymmetrically Coupled TASEP with Mutually Interactive Langmuir Kinetics. J Stat Phys 162, 1571–1586 (2016). https://doi.org/10.1007/s10955-016-1463-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10955-016-1463-6

Keywords

Navigation