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Protonation Equilibria of Some Selected α-Amino Acids in DMSO–Water Mixture and Their Cu(II)-Complexes

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Abstract

The protonation constants of some α-amino acids (glycine (Gly), l-alanine (Ala), l-valine (Val), l-serine (Ser), l-leucine (Leu) and l-isoleucine (Ile)) were studied in water and DMSO–water solution mixtures containing 30, 50 and 70 vol-% DMSO; in addition the complex formation equilibria of their copper(II) complexes were studied by potentiometric technique using a combined pH electrode system calibrated in concentration units of the hydrogen ion at 25 ± 0.1 °C under a nitrogen atmosphere, and at an ionic strength of 0.10 mol·dm−3 NaNO3. The protonation constants and the overall stability constants of copper(II) complexes were influenced by changes in solvent composition, and their variations are discussed in terms of solvent and structural properties.

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Abbreviations

DMSO:

Dimethylsulfoxide

Gly:

Glycine

Ala:

l-alanine

Val:

l-valine

Ser:

l-serine

Leu:

l-leucine

Ile:

l-isoleucine

IMP:

Inosine-5′-monophosphate

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt

    Ahmed A. El-Sherif, Mohamed M. Shoukry & Mohamed M. A. Abd-Elgawad

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  1. Ahmed A. El-Sherif
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  2. Mohamed M. Shoukry
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  3. Mohamed M. A. Abd-Elgawad
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Correspondence to Ahmed A. El-Sherif.

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El-Sherif, A.A., Shoukry, M.M. & Abd-Elgawad, M.M.A. Protonation Equilibria of Some Selected α-Amino Acids in DMSO–Water Mixture and Their Cu(II)-Complexes. J Solution Chem 42, 412–427 (2013). https://doi.org/10.1007/s10953-013-9966-0

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  • DOI: https://doi.org/10.1007/s10953-013-9966-0

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