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Design and Characterization of PVA–Methacrylic Acid Based Smart Polymeric System for Controlled Release of Metoprolol

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Abstract

In the present work covalently crosslinked smart polymeric system of hydrogel based on poly vinyl alcohol (PVA) and methacrylic acid (MA) was designed by free radical polymerization with different compositions using glyoxal (40 % water solution) as crosslinker. It was observed that swelling of hydrogel had a pronounced enhancing effect on increasing the concentration of MA due to availability of more ionized carboxylic groups of MA but produced an opposite effect on increasing the concentration of glyoxal owing to less porous structure. As far as PVA is concerned, swelling did not show significant effect on increasing the concentration of PVA. Hydrophilic polymer PVA rich in hydroxyl group pertained to be highly interactive with water. It was examined that the release of metoprolol tartrate decreased with increased concentration of glyoxal, but increased with increase in concentration of MA. PVA/MA hydrogel was characterized by Fourier transform infrared spectroscopy and X-ray diffraction to study the structure and crystallinity of hydrogel respectively. Morphology was studied through scanning electron microscopy. Furthermore differential scanning calorimetry and thermogravimetric analysis were also performed to characterize thermal stability. It may be concluded that the mechanism of drug release was mainly non-Fickian diffusion.

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Acknowledgments

We would like to thank Higher Education Commission (HEC) Pakistan for initiating programs to provide funds and scholarships for supporting research projects in Pakistan.

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Authors and Affiliations

  1. Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

    Jawad Ahmad Khan, Fahad Pervaiz, Muhammad Naeem, Nayab Khalid & Zeeshan Javaid

  2. Faculty of Pharmacy, Bahaudin Zakariya University, Multan, Pakistan

    Nazar Mohammad Ranjha

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  1. Jawad Ahmad Khan
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  2. Fahad Pervaiz
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  3. Nazar Mohammad Ranjha
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  4. Muhammad Naeem
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  5. Nayab Khalid
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  6. Zeeshan Javaid
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Correspondence to Jawad Ahmad Khan.

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Khan, J.A., Pervaiz, F., Ranjha, N.M. et al. Design and Characterization of PVA–Methacrylic Acid Based Smart Polymeric System for Controlled Release of Metoprolol. J Polym Environ 25, 556–568 (2017). https://doi.org/10.1007/s10924-016-0832-1

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  • DOI: https://doi.org/10.1007/s10924-016-0832-1

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