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Synthesis and Characterization of Surface Modified, Fluorescent and Biocompatible ZnS Nanoparticles with a Hydrophobic Chitosan Derivative

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Abstract

The introduction of a hydrophobic moiety on chitosan enhances the self-assembling properties, mucoadhesion, the permeability of the macromolecule and aids in target specific delivery. Our group synthesized a hydrophobic trans N-(6,6-Dimethyl-2-hepten-4-ynyl)chitosan derivative (CSD) and studied the surface modification of ZnS nanoparticles in a single pot reaction. X-ray diffraction studies and FESEM imaging confirms the nano size and morphology of the surface modified Zinc sulfide nanoparticles (ZnS-CSD NPs). The proposed ZnS-CSD NPs showed excellent emission at 457 nm. Photostability studies indicate that the surface modified ZnS-CSD NPs possess better photostability than Rhodamine B and FITC. Cell viability tests confirmed the biocompatibility of the modified nanoparticles. All these features of ZnS- CSD NPs makes these candidates an excellent choice in a wide range of in vitro or in vivo studies as fluorescent biological labels.

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Authors and Affiliations

  1. Department of Chemistry, Rajalakshmi Engineering College, Thandalam, Chennai, 602105, India

    B. Jothimani & S. Sureshkumar

  2. SRM Easwari Engineering College, Ramapuram, Chennai, 600089, India

    B. Venkatachalapathy

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  1. B. Jothimani
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  2. S. Sureshkumar
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  3. B. Venkatachalapathy
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Correspondence to B. Venkatachalapathy.

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Jothimani, B., Sureshkumar, S. & Venkatachalapathy, B. Synthesis and Characterization of Surface Modified, Fluorescent and Biocompatible ZnS Nanoparticles with a Hydrophobic Chitosan Derivative. J Fluoresc 27, 1277–1284 (2017). https://doi.org/10.1007/s10895-017-2059-5

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  • DOI: https://doi.org/10.1007/s10895-017-2059-5

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