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Heart period and blood pressure characteristics in splanchnic arterial occlusion shock-induced collapse

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Abstract

The nature of hemodynamic instability typical of circulatory shock is not well understood, but an improved interpretation of its dynamic features could help in the management of critically ill patients. The objective of this work was to introduce new metrics for the analysis of arterial blood pressure (ABP) in order to characterize the risk of catastrophic outcome in splanchnic arterial occlusion (SAO) shock. Continuous ABP (fs = 1 kHz) was measured in rats during experimental SAO shock, which induced a fatal pressure drop (FPD) in ABP. The FPD could either be slow (SFPD) or fast (FFPD), with the latter causing cardiovascular collapse. Time series of mean arterial pressure, systolic blood pressure and heart period were derived from ABP. The sample asymmetry-based algorithm Heart Rate Characteristics was adapted to compute the Heart Period Characteristics (HPC) and the Blood Pressure Characteristics (BPC). Baroreflex sensitivity (BRS) was assessed by means of a bivariate model. The approach to FPD of the animals who collapsed (FFPD) was characterized by higher BRS in the low frequency band versus SFPD animals (0.36 ± 0.15 vs. 0.19 ± 0.12 ms/mmHg, p value = 0.0196), bradycardia as indicated by the HPC (0.76 ± 0.57 vs. 1.94 ± 1.27, p value = 0.0179) and higher but unstable blood pressure as indicated by BPC (3.02 ± 2.87 vs. 1.47 ± 1.29, p value = 0.0773). The HPC and BPC indices demonstrated promise as potential clinical markers of hemodynamic instability and impending cardiovascular collapse, and this animal study suggests their test in data from intensive care patients.

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Acknowledgments

This research was supported by the “ShockOmics” Grant #602706 of the European Union, by the “CelSys Shock” Marie Curie International Outgoing Fellowship PIOF-GA-2012-328796 of the European Union in support of the corresponding author, and by National Institutes of Health Grants HL 67825 and GM85072.

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Authors and Affiliations

  1. Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy

    Federico Aletti, Nicolò Gambarotta & Manuela Ferrario

  2. Department of Bioengineering, University of California San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA, 92093-0412, USA

    Federico Aletti, Alexander H. Penn & Geert W. Schmid-Schönbein

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  1. Federico Aletti
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  2. Nicolò Gambarotta
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  3. Alexander H. Penn
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  4. Manuela Ferrario
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  5. Geert W. Schmid-Schönbein
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Correspondence to Federico Aletti.

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Conflict of interest

Geert W. Schmid-Schönbein owns stock in Inflammagen Inc., a company that develops new shock treatments.

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Aletti, F., Gambarotta, N., Penn, A.H. et al. Heart period and blood pressure characteristics in splanchnic arterial occlusion shock-induced collapse. J Clin Monit Comput 31, 167–175 (2017). https://doi.org/10.1007/s10877-015-9813-5

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  • DOI: https://doi.org/10.1007/s10877-015-9813-5

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