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Rocuronium: automatic infusion versus manual administration with TOF monitorisation

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Abstract

TOF (train-of-four) monitoring provides objective data in application of neuromuscular blocking agent. Thus, applicator-based differences are eliminated and optimum muscle relaxation is maintained during operation. In the present study, we aimed to compare the effects of target-controlled infusion system and standard TOF monitoring, on use of rocuronium. ASA I–II patients, who were aged between 18 and 75 years and scheduled for elective abdominal surgery at Haydarpaşa Numune Training and Research Hospital, were enrolled in the study. In order to evaluate neuromuscular blockade, the patients in Group 1 were connected to the acceleromyography device of the target-controlled infusion pump (Veryark-CLMRIS-I-China) while the ones in Group 2 were connected to the routinely used acceleromyography device (TOF Watch SX). There was no significant difference between groups regarding patient characteristics, the durations of anaesthesia and surgery, quality of intubation, time to extubation and time to recovery (TOF ratio of 0.9). Intubation time was significantly longer in Group 1 (Automated group) as compared to Group 2 (Control group) (p < 0.05). The total rocuronium amount used in Group 1 was found to be significantly higher than the amount used in Group 2 (p < 0.05). There was no clinical evidence of residual neuromuscular blockage or reoccurrence of neuromuscular blockage in any patient in either group. Both methods can be used for administration of neuromuscular blocker agent during moderate time anesthesia. No advantage was noted when rocuronium was administered via automatical infusion pump during anaesthesia.

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Authors and Affiliations

  1. Department of Anaesthesiology and Intensive Care, Nigde Bor State Hospital, Nigde, Turkey

    Fatma Gulcin Ozturk Arikan & Bekir Cem Cosar

  2. Department of Anaesthesiology and Intensive Care, Fatih Sultan Mehmet Teaching and Research Hospital, Istanbul, Turkey

    Guldem Turan

  3. Department of Anaesthesiology and Intensive Care, Haydarpasa Numune Teaching and Research Hospital, Istanbul, Turkey

    Asu Ozgultekin

  4. Department of Anaesthesiology and Intensive Care, Trabzon Surmene State Hospital, Trabzon, Turkey

    Zubeyir Sivrikaya

  5. Department of Anaesthesiology and Intensive Care, Nigde State Hospital, Nigde, Turkey

    Dondu Nisa Onder

Authors
  1. Fatma Gulcin Ozturk Arikan
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  2. Guldem Turan
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  3. Asu Ozgultekin
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  4. Zubeyir Sivrikaya
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  5. Bekir Cem Cosar
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Correspondence to Fatma Gulcin Ozturk Arikan.

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Financial disclosure

The authors have no financial relationship with the organization that sponsored the research.

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The authors have no conflict of interest.

Ethics committee approval

Ethics committee approval was received for this study from the ethics committee of Haydarpasa Numune Teaching and Research Hospital (HNEAH-KAEK No: 2012/78).

Informed consent

Written informed consent was obtained from patients who participated in this study.

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Ozturk Arikan, F.G., Turan, G., Ozgultekin, A. et al. Rocuronium: automatic infusion versus manual administration with TOF monitorisation. J Clin Monit Comput 30, 545–550 (2016). https://doi.org/10.1007/s10877-015-9751-2

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  • DOI: https://doi.org/10.1007/s10877-015-9751-2

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