Abstract
Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of different vasopressors on PPV and SVV are unknown. 94 patients undergoing elective otologic surgery were randomly divided into three groups: Group P (patients were given phenylephrine), Group D (patients were given dopamine), Group E (patients were given ephedrine). When surgery was ongoing and the circulation state was stable, patients were given the vasopressor to increase the systolic arterial pressure (SAP) to the pre-calculated levels: low level, 10 % < ΔSAP ≤ 20 %; medium level, 20 % < ΔSAP ≤ 30 %; high level, 30 % < ΔSAP ≤ 40 %. When invasive arterial pressure reached the target value, PPV, SVV and other parameters were recorded. Dopamine decreased the PPV and SVV more significantly than ephedrine, but less significantly than phenylephrine. The influences of phenylephrine, dopamine and ephedrine on SVV and PPV are different due to their different pharmacological mechanisms.
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Acknowledgments
First of all, I would like to extend my sincere gratitude to my supervisor, Wei-dong Mi, for his instructive advice and useful suggestions on my thesis. I am deeply grateful of his help in the completion of this thesis. High tribute shall be paid to Ms. Bin Zhao, whose profound knowledge of English triggers my love for this beautiful language and whose earnest attitude tells me how to learn English. I am also deeply indebted to all the other tutors and teachers in Department of Anesthesiology of People’s Liberation Army General Hospital for their direct and indirect help to me.
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Kong, R., Liu, Y., Mi, W. et al. Influences of different vasopressors on stroke volume variation and pulse pressure variation. J Clin Monit Comput 30, 81–86 (2016). https://doi.org/10.1007/s10877-015-9687-6
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DOI: https://doi.org/10.1007/s10877-015-9687-6