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Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation

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Abstract

Purpose

Little is known about hypogammaglobulinemia (HGG) in asthma patients. No data are available on the characteristics of adult patients with asthma and HGG.

Methods

We conducted a retrospective monocentric study between January 2006 and December 2012. Asthma patients with a serum immunoglobulin (Ig) quantitative analysis were included and classified into two groups depending on their serum IgG concentration: presence or absence of HGG. Clinical, biological, functional, and radiologic characteristics were compared in univariate and multivariate analysis, using a logistic regression model.

Results

In univariate analysis, asthma patients with HGG (n = 25) were older (58 years old ± 18 vs 49 ± 18, p = 0.04) and more frequently active or former smokers as compared to patients with normoglobulinemia (n = 80) (56.0 vs 35.0 %, p = 0.01). Total IgE < 30 kUI/L was more frequently observed in patients with HGG (53.0 vs 18.3 %, p = 0.01). HGG asthma patients had lower fraction of exhaled nitric oxide (p = 0.02), blood eosinophilia (p = 0.0009), and presented with more severe composite score for bronchiectasis (p = 0.01). In multivariate analysis, asthma patients with HGG had increased risk of being smokers [OR = 6.11 (IC 95 % = 1.16–32.04)], having total IgE concentration < 30 kUI/L [OR = 12.87 (IC 95 % = 2.30–72.15)], and a more severe composite score of bronchiectasis [OR = 20.65 (IC 95 % = 2.13–199.74)].

Conclusion

Asthma patients with HGG are older and more often tobacco smoker than asthma patients without HGG. These patients have low type-2 inflammation markers.

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Authors and Affiliations

  1. CHRU Tours, Service de Pneumologie et explorations fonctionnelles respiratoires, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044, F-37044, Tours Cedex, France

    Clairelyne Dupin, Sylvain Marchand-Adam, Philippe Diot & Laurent Guilleminault

  2. Université François Rabelais, UMR 1100, F-37032, Tours, France

    Sylvain Marchand-Adam, Philippe Diot & Laurent Guilleminault

  3. INSERM, Centre d’Etude des Pathologies Respiratoires, UMR 1100/EA6305, F-37032, Tours, France

    Sylvain Marchand-Adam, Philippe Diot & Laurent Guilleminault

  4. CHRU Tours, Groupement d’imagerie médicale, F-37044, Tours, France

    Olivier Favelle

  5. CHRU Tours, service d’information médicale, d’épidémiologie et d’économie de la santé, F-37044, Tours, France

    Romain Costes & Leslie Grammatico-Guillon

  6. CHRU Tours, Service de néphrologie, F-37044, Tours, France

    Philippe Gatault

  7. Equipe Emergente EE1 Education Ethique Santé, Université François-Rabelais, Tours, France

    Leslie Grammatico-Guillon

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  1. Clairelyne Dupin
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  2. Sylvain Marchand-Adam
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Correspondence to Laurent Guilleminault.

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Dupin, C., Marchand-Adam, S., Favelle, O. et al. Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation. J Clin Immunol 36, 810–817 (2016). https://doi.org/10.1007/s10875-016-0335-9

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  • DOI: https://doi.org/10.1007/s10875-016-0335-9

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