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Evolution of nanoparticle-induced distortion on viral polyhedra

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Abstract

Morphological changes in the polyhedra of the Bombyx mori L. nuclear polyhedrosis virus (BmNPV), a baculovirus causing the deadly grasserie disease in silkworms, brought about by mixing with lipophilically capped amorphous silica nanoparticles (LASN, average size 10 ± 2 nm) were studied with scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. SEM shows that the regular octagonal polyhedra facets are replaced by a larger number of newly formed irregular ones. The average number of facets reveals a nonlinear growth pattern with nanoparticle (NP) concentration, where an initial linear region ends in a plateau. IR bands corresponding to vibration modes of the capping show (a) a saturation of the area under the band with NP concentration, indicating a correlation with attachment to viral polyhedra and (b) a narrowing of the band per NP from the linear to the plateau portions of the distortion curve, suggesting non-equilibrium and equilibrium situations, respectively.

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Acknowledgements

The authors would like to thank the Department of Biotechnology, Government of India, (grant nos- BT/PR9050/NNT/28/21/2007, BT/PR15217/NNT/28/506/2011 and BT/BIPP0439/11/10) and Indian Council of Agriculture Research (grant nos- NAIP/Comp-4/C3004/2008-09 and NFBSFARA/GB-2019/2011-12) for their financial support. Indian Statistical Institute (ISI) plan project for 2011–2012 was also used for funding this work. NB thanks the CSIR, New Delhi, for a senior research fellowship.

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Authors and Affiliations

  1. Biological Sciences Division, Indian Statistical Institute, 203, B. T. Road, Kolkata, 700108, India

    Sumistha Das & Arunava Goswami

  2. Applied Material Science Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata, 700064, India

    Alokmay Datta, Smita Mukherjee & Nupur Biswas

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  1. Sumistha Das
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  2. Alokmay Datta
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  3. Smita Mukherjee
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  5. Arunava Goswami
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Correspondence to Sumistha Das.

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Das, S., Datta, A., Mukherjee, S. et al. Evolution of nanoparticle-induced distortion on viral polyhedra. J Biol Phys 39, 173–181 (2013). https://doi.org/10.1007/s10867-013-9304-1

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