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An update on complex I assembly: the assembly of players

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Abstract

Defects in Complex I assembly is one of the emerging underlying causes of severe mitochondrial disorders. The assembly of Complex I has been difficult to understand due to its large size, dual genetic control and the number of proteins involved. Mutations in Complex I subunits as well as assembly factors have been reported to hinder its assembly and give rise to a range of mitochondria disorders. In this review, we summarize the recent progress made in understanding the Complex I assembly pathway. In particularly, we focus on the known as well as novel assembly factors and their role in assembly of Complex I and human disease.

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Acknowledgment

The related work carried out in the authors’ lab has been supported by grants from National Institute of Health (R21 NS072777, and R01 GM109434) to YB.

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  1. Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX, USA

    Rasika S. Vartak, Manpreet Kaur Semwal & Yidong Bai

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  1. Rasika S. Vartak
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  2. Manpreet Kaur Semwal
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Correspondence to Yidong Bai.

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Vartak, R.S., Semwal, M.K. & Bai, Y. An update on complex I assembly: the assembly of players. J Bioenerg Biomembr 46, 323–328 (2014). https://doi.org/10.1007/s10863-014-9564-x

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