Abstract
In this study, morphology effect of nano-hydroxyapatite as a drug carrier was investigated for the first time. Hydroxyapatite/methotrexate (HAp/MTX) hybrids with different morphologies were successfully prepared in situ using polyethylene glycol (PEG) as a template. SEM, TEM, XRD and FTIR results confirmed that the hybrids of different morphologies (laminated, rod-like and spherical) with similar phase composition and functional groups were obtained by changing the preparation parameters. UV–Vis spectroscopy was used to identify the drug loading capacity and drug release mechanism of the three hybrids with different morphologies. It is concluded that the laminated hybrid exhibits a higher drug loading capacity compared to the other two hybrids, and all the three hybrids showed a sustained slow release which were fitted well by Bhaskar equation. Additionally, the result of in vitro bioassay test confirms that the inhibition efficacy of the three hybrids showed a positive correlation to the drug loading capacity.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (grant nos. 51502075, 31660264 and 51662009). And the Outstanding Youth Funds of North China University of Science and Technology (grant no. JP201604).
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Sun, H., Liu, S., Zeng, X. et al. Morphology effect of nano-hydroxyapatite as a drug carrier of methotrexate. J Mater Sci: Mater Med 28, 158 (2017). https://doi.org/10.1007/s10856-017-5978-4
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DOI: https://doi.org/10.1007/s10856-017-5978-4