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Investigating the performance of drug delivery system of fluconazole made of nano–micro fibers coated on cotton/polyester fabric

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Abstract

Polymer-based drug delivery systems are suitable to optimize the therapeutic properties of drugs and to render them safer, more effective and reliable. Long-term or repeated use of oral administration of fluconazole for treating chronic candidiasis in the patient and partially abandoned treatment lead to the resistant strains of the fungus Candida albicans and severity of the disease. In this study, the use of nanofibers and microfibers containing fluconazole for local drug delivery to increase the efficiencies and reduce the side effects caused by taking the drug was studied. Morphology, microstructure and chemical composition of PVA nanofibers containing fluconazole were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). As well as, the DSC test was indicated presence of fluconazole in PVA fibrous mats. The rate of drug release was investigated by UV–Vis spectrophotometery and swelling technique. SEM images showed that the nanofibers with uniform structure without beads were produced. The mechanical properties of the pristine PVA nanofiber and fibrous mat containing drug were evaluated. The release of fluconazole from PVA nanofibers in pH of 7.4 and at 37 °C was investigated. The results presented that the drug release rate is dependent on the morphology and structure of PVA nanofibers and could be adjusted in desired dosage. The presented products are applicable in the high production form for medical textile industry.

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References

  1. Langer R. Polymer-controlled drug delivery systems. Acc Chem Res. 1993;26(10):537–42.

    Article  Google Scholar 

  2. Zeng J, Xu X, Chen X, Liang Q, Bian X, Yang L, Jing X. Biodegradable electrospun fibers for drug delivery. J Control Release. 2003;92(3):227–31.

    Article  Google Scholar 

  3. Ghasemi‐Mobarakeh L, Semnani D, Morshed M. A novel method for porosity measurement of various surface layers of nanofibers mat using image analysis for tissue engineering applications. J Appl Polym Sci. 2007;106(4):2536–42.

    Article  Google Scholar 

  4. Ashjaran A, Namayi A. Survey on nanofiber material as drug delivery systems. Res J Pharm/Biol Chem Sci. 2014;5:1262–74.

    Google Scholar 

  5. Kluger PJ, Wyrwa R, Weisser J, Maierle J, Votteler M, Rode C, Schnabelrauch M, Walles H, Schenke-Layland K. Electrospun poly (d/l-lactide-co-l-lactide) hybrid matrix: a novel scaffold material for soft tissue engineering. J Mater Sci. 2010;21(9):2665–71.

    Google Scholar 

  6. Koosha M, Mirzadeh H. Electrospinning, mechanical properties, and cell behavior study of chitosan/PVA nanofibers. J Biomed Mater Res A. 2015;103(9):3081–93.

    Article  Google Scholar 

  7. Li D, Xia Y. Electrospinning of nanofibers: reinventing the wheel? Adv Mater. 2004;16(14):1151–70.

    Article  Google Scholar 

  8. Bosworth L, Downes S, editors. Electrospinning for tissue regeneration. Cambridge, England: Elsevier; 2011.

  9. Kenawy ER, Abdel-Hay FI, El-Newehy MH, Wnek GE. Processing of polymer nanofibers through electrospinning as drug delivery systems. Mater Chem Phys. 2009;113(1):296–302.

    Article  Google Scholar 

  10. Taylor G. Electrically driven jets. In Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences. The Royal Society; 1969 (Vol. 313, no. 1515, p. 453–475).

  11. Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X. Electrospinning of polymeric nanofibers for drug delivery applications. J Control Release. 2014;185:12–21.

    Article  Google Scholar 

  12. Park JC, Ito T, Kim KO, Kim KW, Kim BS, Khil MS, Kim HY, Kim IS. Electrospun poly (vinyl alcohol) nanofibers: effects of degree of hydrolysis and enhanced water stability. Polym J. 2010;42(3):273–6.

  13. Chen H, Zhang P, He L, Sun J, Wang J, Qin C, Dai L. Preparation of poly (vinyl alcohol) core/sheath micro/nano composite fibers containing silver nanowires. Fibers Polym. 2015;16(10):2251–7.

    Article  Google Scholar 

  14. Kenawy ER, Abdel-Hay FI, El-Newehy MH, Wnek GE. Controlled release of ketoprofen from electrospun poly (vinyl alcohol) nanofibers. Mater Sci Eng A. 2007;459(1):390–6.

    Article  Google Scholar 

  15. Ding B, Kim HY, Lee SC, Shao CL, Lee DR, Park SJ, Kwag GB, Choi KJ. Preparation and characterization of a nanoscale poly (vinyl alcohol) fiber aggregate produced by an electrospinning method. J Polym Sci Part B. 2002;40(13):1261–8.

    Article  Google Scholar 

  16. Pathan SG, Fitzgerald LM, Ali SM, Damrauer SM, Bide MJ, Nelson DW, Ferran C, Phaneuf TM, Phaneuf MD. Cytotoxicity associated with electrospun polyvinyl alcohol. J Biomed Mater Res Part B. 2015;103(8):1652–62.

    Article  Google Scholar 

  17. Gimenez V, Mantecon A, Cadiz V. Crosslinking of poly (vinyl alcohol) using dianhydrides as hardeners. J Appl Polym Sci. 1996;59(3):425–31.

    Article  Google Scholar 

  18. McCreath KJ, Specht CA, Robbins PW. Molecular cloning and characterization of chitinase genes from Candida albicans. Proc Natl Acad Sci. 1995;92(7):2544–8.

    Article  Google Scholar 

  19. Calderone RA, Clancy CJ. editors. Candida and candidiasis. Washington, DC, USA: American Society for Microbiology Press; 2011.

  20. De Cremer K, De Brucker K, Staes I, Peeters A, Van den Driessche F, Coenye T, Cammue BP, Thevissen K. Stimulation of superoxide production increases fungicidal action of miconazole against Candida albicans biofilms. Sci Rep. 2016;6:27463.

    Article  Google Scholar 

  21. Ferrer J. Vaginal candidosis: epidemiological and etiological factors. Int J Gynecol Obstet. 2000;71:21–7.

    Article  Google Scholar 

  22. Coneac G, et al. Development and evaluation of new microemulsion-based hydrogel formulations for topical delivery of fluconazole. AAPS PharmSciTech. 2015;16(4):889–904.

    Article  Google Scholar 

  23. Matar M, Ostrosky-Zeichner L, Paetznick VL, Rodriguez JR, Chen E, Rex JH. Correlation between Etest, disk diffusion, and microdilution methods for antifungal susceptibility testing of fluconazole and voriconazole. Antimicrob Agents Chemother. 2003;47:1647–51.

    Article  Google Scholar 

  24. Baghersad S, Mansurnezhad R, Ghasemi-Mobarakeh L, Molahosseini H, Morshed M. Coating of silk fabrics by PVA/ciprofloxacin HCl nanofibers for biomedical applications. Iran J Polym Sci Technol 2016;29(2):171–84.

  25. Norouzi M, Ghasemi-Mobarakeh L, Morshed M. Fabrication of antibacterial poly(vinyl alcohol) microfibers mat for wound dressing application. Iran J Polym Sci Technol. 2016;29(1):15–25.

    Google Scholar 

  26. Zhang Y, Ouyang H, Lim CT, Ramakrishna S, Huang ZM. Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. J Biomed Mater Res Part B. 2005;72(1):156–65.

    Article  Google Scholar 

  27. Wayne PA. Clinical and laboratory standards institute. Performance standards for antimicrobial susceptibility testing. 27th ed. CLSI supplement M100. 2007.

  28. Shehap AM. Thermal and spectroscopic studies of polyvinyl alcohol/sodium carboxy methyl cellulose blends. Egypt J Solids. 2008;31(1):75–91.

    Google Scholar 

  29. Cyr TD, et al. Spectral characterization of fluconazole. J Pharm Biomed Anal. 1996;14(3):247–55.

    Article  Google Scholar 

  30. Prabhu P, et al. Investigation of hydrogel membranes containing combination of gentamicin and dexamethasone for ocular delivery. Int J Pharm Investig. 2015;5(4):214.

    Article  Google Scholar 

  31. Patel S, Shah D, Tiwari S. Bioadhesive films containing fluconazole for mucocutaneous candidiasis. Indian J Pharm Sci. 2015;77(1):55.

    Article  Google Scholar 

  32. Brough C, et al. Use of polyvinyl alcohol as a solubility-enhancing polymer for poorly water soluble drug delivery (part 1). AAPS PharmSciTech. 2016;17(1):167–79.

    Article  Google Scholar 

  33. Thompson CJ, Chase GG, Yarin AL, Reneker DH. Effects of parameters on nanofiber diameter determined from electrospinning model. Polymer. 2007;48(23):6913–22.

    Article  Google Scholar 

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Acknowledgements

The authors are appreciated the support of the Isfahan University of technology and Ms. Neda Tansazan for providing DSC test

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Authors and Affiliations

  1. Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran

    Dariush Semnani, Mehran Afrashi & Farzaneh Alihosseini

  2. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Parvin Dehghan & Mehrnoosh Maherolnaghsh

Authors
  1. Dariush Semnani
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  2. Mehran Afrashi
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  3. Farzaneh Alihosseini
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  4. Parvin Dehghan
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  5. Mehrnoosh Maherolnaghsh
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Correspondence to Dariush Semnani.

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Semnani, D., Afrashi, M., Alihosseini, F. et al. Investigating the performance of drug delivery system of fluconazole made of nano–micro fibers coated on cotton/polyester fabric. J Mater Sci: Mater Med 28, 175 (2017). https://doi.org/10.1007/s10856-017-5957-9

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  • DOI: https://doi.org/10.1007/s10856-017-5957-9

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