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A self-regulating antimicrobial model based on the ion-exchange stimuli

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Abstract

In this study, a novel intelligent antimicrobial model was constructed based on the antibiotic properties of nano-silver and the ion-exchange response of dehydrated alginate (Alg) gel. Through the process of reducing reaction, hydrogel formation and dehydration, the model composed of Alg and nano-silver was fabricated. The distinguished feature of this model lies in its antimicrobial properties and biocompatibility. In this model, the releasing level of nano-silver is determined by the outside-in swelling of Alg composites, which is further self-regulated by the volume of wound exudates. The results showed that the released nano-silver was intelligently maintained within a constant concentration range, so that it could be further designed to exhibit antimicrobial activity without cytotoxicity. Furthermore, the murine wound infection model conducted with these composites resulted in a significant decrease of bacteria number. The self-regulating swelling feature based on the ion-exchange response of Alg along with the controlled release of nano-silver made this composite a promising intelligent model for antimicrobial wound dressing applications.

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Acknowledgments

This work was supported by the Natural Science Foundation of Shanxi Province (2012021021-7), the National Nature Science Foundation of China (31300808 and 31400815) and Scientific and Technologial Innovation Programs of Higher Education Institutions in Shanxi (201417) and Taiyuan University of Technology Graduate Innovation Fund (S2014081).

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Authors and Affiliations

  1. Research Institute of Surface Engineering, Taiyuan University of Technology, 79 Yingze Road, Taiyuan, 030024, People’s Republic of China

    Xiaobo Huang, Yinping Liu, Chengliang Chang, Longan Jiao, Ruiqiang Hang & Bin Tang

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  1. Xiaobo Huang
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  2. Yinping Liu
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  3. Chengliang Chang
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  4. Longan Jiao
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  5. Ruiqiang Hang
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Correspondence to Xiaobo Huang.

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Huang, X., Liu, Y., Chang, C. et al. A self-regulating antimicrobial model based on the ion-exchange stimuli. J Mater Sci: Mater Med 26, 208 (2015). https://doi.org/10.1007/s10856-015-5546-8

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  • DOI: https://doi.org/10.1007/s10856-015-5546-8

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