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\( {\alpha^{\prime}}_{\text{H}} \)-Dicalcium silicate bone cement doped with tricalcium phosphate: characterization, bioactivity and biocompatibility

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Abstract

The influence of phosphorus doping on the properties of \( \alpha^{\prime}_{\text{H}} \)-dicalcium silicate (C2S) bone cement was analyzed, in addition to bioactivity and biocompatibility. All the cements were composed of a solid solution of TCP in C2S (\( \alpha^{\prime}_{\text{H}} \)-C2Sss) as the only phase present. The compressive strength ranged from 3.8–16.3 MPa. Final setting times ranged from 10 to 50 min and were lower for cements with lower L/P content. Calcium silicate hydrate was the principal phase formed during the hydration process of the cements. The cement exhibited a moderate degradation and could induce carbonated hydroxyapatite formation on its surface and into the pores. The cell attachment test showed that the \( \alpha^{\prime}_{\text{H}} \)-Ca2SiO4 solid solution supported human adipose stem cells adhesion and spreading, and the cells established close contacts with the cement after 24 h of culture. The novel \( \alpha^{\prime}_{\text{H}} \)-C2Sss cements might be suitable for potential applications in the biomedical field, preferentially as materials for bone/dental repair.

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Acknowledgments

Part of this work was supported by Generalitat Valenciana ACOM/2009/173.

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Authors and Affiliations

  1. Instituto de Bioingeniería, Universidad Miguel Hernández, Avda. de la Universidad s/n, 03202, Elche, Alicante, Spain

    Piedad N. de Aza, Pablo Velasquez, Nestor Vicente-Salar & Juan A. Reig

  2. Escuela de Arquitectura y Diseño, Universidad Pontificia Bolivariana, Circular 1 Nº 70-01, Bloque 10 Of 306, Medellín, Antioquia, Colombia

    Fausto Zuleta

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  1. Piedad N. de Aza
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Correspondence to Piedad N. de Aza.

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de Aza, P.N., Zuleta, F., Velasquez, P. et al. \( {\alpha^{\prime}}_{\text{H}} \)-Dicalcium silicate bone cement doped with tricalcium phosphate: characterization, bioactivity and biocompatibility. J Mater Sci: Mater Med 25, 445–452 (2014). https://doi.org/10.1007/s10856-013-5084-1

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  • DOI: https://doi.org/10.1007/s10856-013-5084-1

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