Article

Journal of Materials Science: Materials in Medicine

, Volume 24, Issue 11, pp 2549-2559

Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat

  • Zengjuan ZhengAffiliated withCollege of Pharmacy and Biological Science, Weifang Medical University
  • , Weifen ZhangAffiliated withCollege of Pharmacy and Biological Science, Weifang Medical University Email author 
  • , Weiqing SunAffiliated withHangzhou Singclean Medical Products Co., Ltd.
  • , Xiaojian LiAffiliated withDrug Development Division, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky
  • , Jinghua DuanAffiliated withDrug Development Division, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky
  • , Juanjuan CuiAffiliated withCollege of Pharmacy and Biological Science, Weifang Medical University
  • , Zhanqin FengAffiliated withCollege of Pharmacy and Biological Science, Weifang Medical University
  • , Heidi M. MansourAffiliated withDrug Development Division, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.