Journal of Materials Science: Materials in Medicine

, Volume 24, Issue 11, pp 2549–2559

Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat

  • Zengjuan Zheng
  • Weifen Zhang
  • Weiqing Sun
  • Xiaojian Li
  • Jinghua Duan
  • Juanjuan Cui
  • Zhanqin Feng
  • Heidi M. Mansour
Article

DOI: 10.1007/s10856-013-4981-7

Cite this article as:
Zheng, Z., Zhang, W., Sun, W. et al. J Mater Sci: Mater Med (2013) 24: 2549. doi:10.1007/s10856-013-4981-7

Abstract

The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Zengjuan Zheng
    • 1
  • Weifen Zhang
    • 1
  • Weiqing Sun
    • 2
  • Xiaojian Li
    • 3
  • Jinghua Duan
    • 3
  • Juanjuan Cui
    • 1
  • Zhanqin Feng
    • 1
  • Heidi M. Mansour
    • 3
  1. 1.College of Pharmacy and Biological Science, Weifang Medical UniversityWeifangPeople’s Republic of China
  2. 2.Hangzhou Singclean Medical Products Co., Ltd.HangzhouPeople’s Republic of China
  3. 3.Drug Development Division, Department of Pharmaceutical SciencesCollege of Pharmacy, University of KentuckyLexingtonUSA