Journal of Materials Science: Materials in Medicine

, Volume 24, Issue 11, pp 2549–2559

Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat

Authors

  • Zengjuan Zheng
    • College of Pharmacy and Biological Science, Weifang Medical University
    • College of Pharmacy and Biological Science, Weifang Medical University
  • Weiqing Sun
    • Hangzhou Singclean Medical Products Co., Ltd.
  • Xiaojian Li
    • Drug Development Division, Department of Pharmaceutical SciencesCollege of Pharmacy, University of Kentucky
  • Jinghua Duan
    • Drug Development Division, Department of Pharmaceutical SciencesCollege of Pharmacy, University of Kentucky
  • Juanjuan Cui
    • College of Pharmacy and Biological Science, Weifang Medical University
  • Zhanqin Feng
    • College of Pharmacy and Biological Science, Weifang Medical University
    • Drug Development Division, Department of Pharmaceutical SciencesCollege of Pharmacy, University of Kentucky
Article

DOI: 10.1007/s10856-013-4981-7

Cite this article as:
Zheng, Z., Zhang, W., Sun, W. et al. J Mater Sci: Mater Med (2013) 24: 2549. doi:10.1007/s10856-013-4981-7

Abstract

The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.

Copyright information

© Springer Science+Business Media New York 2013