Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat
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The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.
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- Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat
Journal of Materials Science: Materials in Medicine
Volume 24, Issue 11 , pp 2549-2559
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- 1. College of Pharmacy and Biological Science, Weifang Medical University, 7166# Baotong Road, Weifang, 261053, People’s Republic of China
- 2. Hangzhou Singclean Medical Products Co., Ltd., Hang Zhou Western Lake, Hangzhou, 311402, Zhejiang, People’s Republic of China
- 3. Drug Development Division, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St, Lexington, KY, 40536-0596, USA