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Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun fiber mats

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Abstract

To improve the poor compatibility among different components of Drug-in-adhesive type patch, two novel plasters (Drug-in-fiber and Drug-in-adhesive/fiber) were developed based on ibuprofen (IBU)-loaded fiber mats. These fibrous mats were fabricated via electrospinning of cellulose acetate/poly(vinylpyrrolidone) composites in a binary solvent of N,N-dimethyl acetamide/acetone. Physical status studies suggested that Drug-in-fiber could inhibit IBU re-crystallization, but the active ingredients were released at a relatively slow rate due to the dual-resistance of fiber mat and adhesive matrix. To overcome this shortcoming, Drug-in-adhesive/fiber was designed by coupling medicated hydrophilic pressure sensitive adhesive and IBU-loaded fiber mat. This method endowed Drug-in-adhesive/fiber a fast IBU release rate and high permeated drug amount though simulative skins. This design separated enhancer from adhesive matrix, which guaranteed Drug-in-adhesive/fiber excellent adhesion forces. Hence, the plasters based on medicated fiber mats improved the compatibility among patch components.

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Acknowledgments

This project was supported by the National Natural Science Foundation of China (No. 81041085; 51103097).

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  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    Yongli Shi, Shuxin Xu, Anjie Dong & Jianhua Zhang

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  1. Yongli Shi
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  2. Shuxin Xu
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  4. Jianhua Zhang
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Correspondence to Jianhua Zhang.

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Shi, Y., Xu, S., Dong, A. et al. Design and in vitro evaluation of transdermal patches based on ibuprofen-loaded electrospun fiber mats. J Mater Sci: Mater Med 24, 333–341 (2013). https://doi.org/10.1007/s10856-012-4805-1

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  • DOI: https://doi.org/10.1007/s10856-012-4805-1

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