Article

Journal of Materials Science: Materials in Medicine

, Volume 21, Issue 1, pp 377-384

Effect of strontium-containing hydroxyapatite bone cement on bone remodeling following hip replacement

  • Guo X. NiAffiliated withDepartment of Rehabilitation Medicine, Fujian Medical University Email author 
  • , Jian H. LinAffiliated withDepartment of Orthopaedic Surgery, No. 1 Affiliated Hospital, Fujian Medical University
  • , Peter K. Y. ChiuAffiliated withDepartment of Orthopaedics and Traumatology, The University of Hong Kong
  • , Zhao Y. LiAffiliated withDepartment of Orthopaedics and Traumatology, The University of Hong Kong
  • , William W. LuAffiliated withDepartment of Orthopaedics and Traumatology, The University of Hong Kong Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

It is uncertain whether the use of bioactive bone cement has any beneficial effect on local bone adaptation following hip replacement. In this study, twelve goats underwent cemented hip hemiarthroplasty unilaterally, with either PMMA bone cement or strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement. Nine months later, the femoral cortical bones at different levels were analyzed by microhardness testing and micro-CT scanning. Extensive bone remodeling was found at proximal and mid-levels in both PMMA and Sr-HA groups. However, with regard to the differences of bone mineral density, cortical bone area and bone hardness between implanted and non-implanted femur, less decreases were found in Sr-HA group than PMMA group at proximal and mid-levels, and significant differences were shown for bone area and hardness at proximal level. The results suggested that the use of Sr-HA cement might alleviate femoral bone remodeling after hip replacement.