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Innovation in multifunctional bioabsorbable osteoconductive drug-releasing hard tissue fixation devices

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Abstract

We review in this paper the work performed by our group to develop multifunctional bioabsorbable ciprofloxacin releasing bone implants. Poly lactide-co-glycolide (PLGA 80/20 and polylactide (P(L/DL)LA 70/30) were used. Ciprofloxacin (CF) and bioactive glass (BaG) 13-93 were added. The mixture was then extruded and self-reinforced. CF release, mechanical strength, and the effect on S. epidermidis attachment and biofilm formation were evaluated. In rabbits, tissue reactions were assessed. Pull out strength was evaluated in cadaver bones. CF was released over 44 weeks (P(L/DL)LA) and 23–26 weeks (PLGA). Initial shear strength of the CF screws was 152 MPa (P(L/DL)LA) and 172 MPa (PLGA). Strength was retained for 12 weeks (P(L/DL)LA) and 9 weeks (PLGA). Histologically, CF releasing implants did not show much difference from control plain PLGA screws except for increased giant cells. CF miniscrews had lower pullout strength than the controls, but CF tacks had better values than controls. BaG led to a drop in pullout strength properties. Bacterial growth, attachment and biofilm formation on CF implants was significantly reduced when compared to controls. Accordingly, bioabsorbable multifunctional implants with appropriate CF release, mechanical, and biocompatibility properties are possible to develop and are considered appropriate to apply clinically.

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References

  1. H. W. BUCHOLZ and, E. ENGELBRECHT, Chirug. 41 (1970) 511.

    Google Scholar 

  2. N. ASHAMMAKHI, R. SUURONEN, J. TIAINEN, P. TöRMäLä and, T. WARIS, J. Craniofac. Surg. 14 (2003) 247.

    Article  Google Scholar 

  3. R. SUURONEN, R. KONTIO, N. ASHAMMAKHI, C. LINDQVIST, and, P. LAINE, Biomed. Mater. Eng. 14 (2004) 517.

    Google Scholar 

  4. E. WARIS, M. NINKOVIC, C. HARPF and N. ASHAMMAKHI, J. Hand Surg. [Am] 29 (2004) 452.

    Article  Google Scholar 

  5. K. L. GARVIN, J. A. MIYANO, D. ROBINSON, D. GIGER, J. NOVAK and S. RADIO, J. Bone Joint Surg. 76-A (1994) 1500.

    Google Scholar 

  6. J. OVERBECK, S. WINCKLER, R. MEFFERT, P. TöRMäLä, H. SPIEGEL and E. BRUG, J. Investigational Surg. 8 (1995) 155.

    CAS  Google Scholar 

  7. J. CALHOUN and, J. MADER, Clin. Orthop. Rel. Res. 341 (1997) 206.

    Article  Google Scholar 

  8. H. P. LAMBERT, and, F. W. ÓGRADY, in “Antibiotic and Chemotherapy” (Churchill Livingstone, Edinburgh, 1992) p. 245.

    Google Scholar 

  9. R. ANSORG, K. D. MULLER and J. WIORA, Chemotherapy 36 (1990) 222.

    Article  CAS  Google Scholar 

  10. R. WISE, J. M. ANDREWS and L. J. EDWARDS, Antimicrob. Agents Chemother. 23 (1983) 559.

    CAS  Google Scholar 

  11. L. CLAES, K. REHM and D. HUTMACHER, in Proceedings of the Fourth World Biomaterials Congress, Berlin, April 1992 (Transactions, 1992) p. 205.

  12. J. BLASER, B. B. STONE, M. C. GRONER and, S. H. ZINNER, Antimicrob. Agents Chemother. 31 (1987) 1054.

    CAS  Google Scholar 

  13. P. TöRMäLä, Clin. Mater. 10 (1992) 29.

    Article  Google Scholar 

  14. J. TIAINEN, M. VEIRANTO, E. SUOKAS, P. TöRMäLä, T. WARIS, M. NINKOVIC, and, N. ASHAMMAKHI, J. Craniofac. Surg. 13 (2002) 427.

    Article  Google Scholar 

  15. J. TIAINEN, S. LEINONEN, J. ILOMäKI, E. SUOKAS, P. TöRMäLä, T. WARIS and, N. ASHAMMAKHI, J. Craniofac. Surg. 13 (2002) 538.

    Article  Google Scholar 

  16. S. LEINONEN, J. TIAINEN, M. KELLOMäKI, P. TöRMäLä, T. WARIS, N. ASHAMMAKHI and, M. NINKOVIC, J. Craniofac. Surg. 14 (2003) 171.

    Article  Google Scholar 

  17. S. LEINONEN, E. SUOKAS, M. VEIRANTO, P. TöRMäLä, T. WARIS and, N. ASHAMMAKHI, J. Craniofac. Surg. 13 (2002) 212.

    Article  Google Scholar 

  18. J. TIAINEN, K. KNUUTILA, M. VEIRANTO, E. SUOKAS, T. WARIS, P. TöRMäLä, O. KAARELA and, N. ASHAMMAKHI, in Proceedings of the XVIIth European Congress for Cranio-Maxillofacial Surgery, Tours, France, September 2004 (Churchill Livingstone, Edinburgh, 2004) p. 556.

    Google Scholar 

  19. S.-M. NIEMELä, I. IKäHEIMO, M. KOSKELA, M. VEIRANTO, E. SUOKAS, P. TöRMäLä, T. WARIS, N. ASHAMMAKHI, and, H. SYRJäLä, J. Biomed. Mater. Res. (Appl. Biomat.) 76 (2006) 8.

    Article  CAS  Google Scholar 

  20. J. TIAINEN, Y. SOINI, E. SUOKAS, M. VEIRANTO, P. TöRMäLä, T. WARIS and N. ASHAMMAKHI, J. Mater. Sci. Mater. Med. (Accepted) .

  21. J. TIAINEN, Y. SOINI, P. TöRMäLä, T. WARIS and N. ASHAMMAKHI, J. Biomed. Mater. Res. (Appl. Biomat.) 70B (2004) 49.

    Article  CAS  Google Scholar 

  22. M. VEIRANTO, E. SUOKAS, N. ASHAMMAKHI and, P TöRMäLä, in Biomaterials: From Molecules to Engineered Tissues, edited by N. Hasirci and V. Hasirci (Kluwer Academic/Plenum Publishers, 2004) p. 197.

  23. M. VEIRANTO, E. SUOKAS and, P. TöRMäLä, J. Mater. Sci.: Mater. Med. 13 (2002) 1259.

    Article  CAS  Google Scholar 

  24. M. VEIRANTO, E. SUOKAS, N. ASHAMMAKHI and, P. TöRMäLä , Adv. Exp. Med. Biol. 553 (2004) 197.

    CAS  Google Scholar 

  25. K. KNUUTILA, Development and characterization of antibiotic releasing minitacks. MSc Thesis (2004) Institute of Biomaterials, Tampere University of Technology, Tampere, Finland.

  26. Y. H. AN, S. K. WOOLF and, R. J. FRIEDMAN, Biomaterials 21 (2000) 2635.

    Article  CAS  Google Scholar 

  27. W. A. CRAIG, in “Antimicrobial Pharmacodynamics in Theory and Clinical Practice” (Marcel Dekker Inc., New York, 2002) p. 1.

    Google Scholar 

  28. N. ASHAMMAKHI and, P. TöRMäLä, Editorial. From past to present and future is today. From inert to multifunctional biomaterials. J. Craniofac. Surg. 15 (2004) 897.

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Biomaterials, Tampere University of Technology, Tampere, Finland

    N. Ashammakhi, M. Veiranto & P. Törmälä

  2. Department of Surgery, Oulu University Hospital, Oulu, Finland

    N. Ashammakhi, J. Tiainen & S.-M. Niemelä

  3. Linvatec Biomaterials Ltd., Tampere, Finland

    E. Suokas

Authors
  1. N. Ashammakhi
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  2. M. Veiranto
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  3. E. Suokas
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  4. J. Tiainen
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  5. S.-M. Niemelä
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  6. P. Törmälä
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Correspondence to N. Ashammakhi.

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Ashammakhi, N., Veiranto, M., Suokas, E. et al. Innovation in multifunctional bioabsorbable osteoconductive drug-releasing hard tissue fixation devices. J Mater Sci: Mater Med 17, 1275–1282 (2006). https://doi.org/10.1007/s10856-006-0602-z

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  • DOI: https://doi.org/10.1007/s10856-006-0602-z

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