Abstract
PPY nanoparticles, as one of the important organic photothermal agents has been attracted great attention due to their good biocompatibility, high photothermal efficiency, and low cost. In order to further evaluate the size-dependent photothermal effect, PPY nanoparticles with two different sizes have been prepared with a facile method. The near infrared absorption and photothermal effect of the two size PPY nanoparticles were compared. The PPY nanoparticle with small size shows better photothermal effect at the same condition. The photostability, stability, and cytotoxicity in biologic system have also been investigated. In addition, the PPY nanoparticles with small size can kill the cancer cells effectively under the irradiation of 808 nm laser with a low-power density. These findings may provide better information for the application of the PPY nanoparticles on the photothermal ablation of cancer cells.
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Acknowledgements
The authors gratefully acknowledge the financial support by the Shanghai Municipal Nature Science Foundation (Grant No. 13ZR1433300), the Shanghai Committee of Science and Technology, China (Grant No. 11JC1410400), the Shanghai Jiao Tong University Biomedical Engineering (Physical) Crossover Foundation (Grant No. YG2011MS57), the National Natural Science Foundation of China (Grant Nos. 21171035 and 51302035), the Key Grant Project of Chinese Ministry of Education (Grant No. 313015), the PhD Programs Foundation of the Ministry of Education of China (Grant Nos. 20110075110008 and 20130075120001), the National 863 Program of China (Grant No. 2013AA031903), the Science and Technology Commission of Shanghai Municipality (Grant No. 13ZR1451200), the Fundamental Research Funds for the Central Universities, Program for Changjiang Scholars and Innovative Research Team in University (Grant No. IRT1221), the Shanghai Leading Academic Discipline Project (Grant No. B603), and the Program of Introducing Talents of Discipline to Universities (No. 111-2-04).
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Wang, Q., Wang, J., Lv, G. et al. Facile synthesis of hydrophilic polypyrrole nanoparticles for photothermal cancer therapy. J Mater Sci 49, 3484–3490 (2014). https://doi.org/10.1007/s10853-014-8061-2
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DOI: https://doi.org/10.1007/s10853-014-8061-2