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Preparation, in-vitro release and antioxidant potential of formulation of apigenin with hydroxypropyl-β-cyclodextrin modified microemulsion

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Abstract

This work was carried out to exploit the feasibility of microemulsion combining apigenin/hydroxypropyl-β-cyclodextrin (API/HP-β-CD) complex as the carrier for improving the solubility of API, a bioactive flavonoid with various pharmacological activities. The API/HP-β-CD complex in solid state was prepared by solvent-freeze-drying method and characterized by FT-IR, PXRD and 1H NMR. To further increase the solubility of API, the complex of HP-β-CD with food-grade cosurfactant-free microemulsion was constructed. The aqueous solubility of API significantly increases in the HP-β-CD/Microemulsion complex, via solubilizing dominantly into the “palisade” layer, minor outer phase and inner core. The HP-β-CD modified microemulsion improves the cumulative percentage of API released. Moreover, API loaded in microemulsions with HP-β-CD had a higher antioxidant activity than that without HP-β-CD.

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Acknowledgments

Support of this work by the National Natural Science Foundation of China (31271933, 31071603) is gratefully acknowledged. The authors also thank Dr. F. Liu for help in UV–Vis spectroscopy analysis.

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, 250014, People’s Republic of China

    Xin Zhao, Zhongni Wang & Xuepeng Li

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  1. Xin Zhao
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Correspondence to Zhongni Wang.

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Zhao, X., Wang, Z. & Li, X. Preparation, in-vitro release and antioxidant potential of formulation of apigenin with hydroxypropyl-β-cyclodextrin modified microemulsion. J Incl Phenom Macrocycl Chem 86, 93–102 (2016). https://doi.org/10.1007/s10847-016-0644-x

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  • DOI: https://doi.org/10.1007/s10847-016-0644-x

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