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Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk.

Methods

A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size.

Result

Eleven case–control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09–1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy–Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76–2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83–1.42).

Conclusions

IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.

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Acknowledgments

This work was supported by the National Basic Research Program of China (973 Program, 2012CB947600) and the National Natural Science Foundation of China (31070676, 90919006, and 31300961). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Medical Genetics and Division of Human Morbid Genomics, West China Hospital, Sichuan University, 1st Keyuan 4 Lu, High-Tech Zone, Chengdu, 610041, China

    Chongjuan Gu, Zhao Yang & Yongxin Ma

  2. Provincial Key Laboratory for Molecular Medicine of Major Diseases and Prevention and Treatment with Traditional Chinese Medicine of Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China

    Hongxia Gong

  3. Department of Obstetrics and Gynecology, reproductive medicine centre, Southwest Hospital, Third Military Medical University, Chongqing, China

    Zheng Zhang

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  1. Chongjuan Gu
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  2. Hongxia Gong
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  3. Zheng Zhang
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  4. Zhao Yang
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  5. Yongxin Ma
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Correspondence to Yongxin Ma.

Additional information

Capsule IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.

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Gu, C., Gong, H., Zhang, Z. et al. Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis. J Assist Reprod Genet 33, 907–917 (2016). https://doi.org/10.1007/s10815-016-0699-z

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  • DOI: https://doi.org/10.1007/s10815-016-0699-z

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