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Serum Anti-müllerian hormone, follicle stimulating hormone and antral follicle count measurement cannot predict pregnancy rates in IVF/ICSI cycles

  • ASSISTED REPRODUCTION TECHNOLOGIES
  • Published:
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Abstract

Purpose

To investigate whether serum anti-müllerian hormone (AMH), follicle stimulating hormone (FSH), or antral follicle count (AFC) are predictive for clinical pregnancy in in vitro fertilization (IVF) patients.

Methods

Serum AMH, inhibin B, FSH, luteinizing hormone (LH), estradiol (E2), prolactin, and thyroid stimulating hormone (TSH) levels and AFC of 189 women under 40 years of age were investigated. Pregnant and non-pregnant women were compared.

Results

Forty-seven (24.8 %) clinical pregnancies were observed in 189 women. There was no significant difference in terms of mean age, duration of infertility, body mass index, AMH, LH, FSH, E2, TSH, Inhibin B, AFC and total oocyte number between women who did and who did not become pregnant. Additionally, there was no significant difference in clinical pregnancy rates between the quartiles of AMH, FSH and AFC. (P values were 0.668, 0.071, and 0.252, respectively.)

Conclusion

Serum AMH and FSH, and AFC cannot predict clinical pregnancy in IVF patients under 40; the pregnancy rate tends to increase as AMH increases, although this remains non-significant.

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Acknowledgements

We would like to thank Begum Aydogan MD, Nil Atakul, MD, Sarper Erdogan, PhD, Hulya Senol, Naciye Erol, Birsen Yıldız, Neslihan Bardak Gürel and Mutlu Tezel for their sincere support and technical assistance.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkey

    Sezai Sahmay, Pelin Ocal, Levent M. Senturk & Engin Oral

  2. Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkey

    Gökhan Demirayak & Onur Guralp

  3. Department of Obstetrics and Gynecology, Division of Embryology, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkey

    Tulay Irez

  4. Istanbul Universitesi, Cerrahpasa Tip Fakultesi, Kadin Hastaliklari ve Dogum Anabilim Dali, Fatih, Istanbul, Turkey

    Pelin Ocal

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  1. Sezai Sahmay
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  3. Onur Guralp
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  4. Pelin Ocal
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Corresponding author

Correspondence to Pelin Ocal.

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Capsule

Serum AMH and FSH, and AFC cannot predict clinical pregnancy in IVF patients under 40; the pregnancy rate tends to increase as AMH increases, although this remains non-significant.

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Sahmay, S., Demirayak, G., Guralp, O. et al. Serum Anti-müllerian hormone, follicle stimulating hormone and antral follicle count measurement cannot predict pregnancy rates in IVF/ICSI cycles. J Assist Reprod Genet 29, 589–595 (2012). https://doi.org/10.1007/s10815-012-9754-6

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  • DOI: https://doi.org/10.1007/s10815-012-9754-6

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