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IVM is an alternative for patients with PCO after failed conventional IVF attempt

  • Assisted reproductive Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To determine if IVM of oocytes from unstimulated cycle is a treatment option for patients who did not deliver after standard IVF-ET.

Method

Twenty three women with PCO, thirteen of them with normal cycles and all <35 years old, who failed IVF served as their own control. During the control IVF cycle patients were stimulated with 1730.7 ± 639.5 IU recombinant FSH, a long Buserelin acetate protocol was used and embryo transfer was performed on day 2 or 3 after ICSI. After failed IVF immature oocytes were aspirated transvaginally from antral follicles during spontaneous menstrual cycle. Embryo transfer was performed 2 or 3 days later.

Result

11.4 ± 4.8 mature oocytes and 6.7 ± 3.2 embryos were produced with IVF, which served as the control, compared to 9.7 ± 4.5 mature oocytes and 6.2 ± 3.2 embryos with IVM. There was one clinical pregnancy in the IVF group which did not result in a live birth where as five singleton and one pair of twins with healthy live births and one miscarriage in the IVM group.

Conclusion

IVM does not involve ovarian stimulation with possible financial and health consequences. İt may be an useful treatment after unsuccessful IVF.

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Authors and Affiliations

  1. Department of Obstetrics & Gynecology, School of Medicine, Dokuz Eylul University Hospital, Izmir, Turkey

    Bulent Gulekli, Muge Kovali, Fulya Aydiner, Sule Dogan & Seda S. Dogan

  2. Division of Reproductive Endocrinology & IVF Unit, Izmir, Turkey

    Bulent Gulekli

Authors
  1. Bulent Gulekli
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  2. Muge Kovali
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  3. Fulya Aydiner
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  4. Sule Dogan
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  5. Seda S. Dogan
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Corresponding author

Correspondence to Bulent Gulekli.

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Capsule

In vitro maturation of oocytes from unstimulated ovaries after unsuccessful in vitro fertilization attempt

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Gulekli, B., Kovali, M., Aydiner, F. et al. IVM is an alternative for patients with PCO after failed conventional IVF attempt. J Assist Reprod Genet 28, 495–499 (2011). https://doi.org/10.1007/s10815-011-9591-z

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  • DOI: https://doi.org/10.1007/s10815-011-9591-z

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