We have used Fourier transform IR spectroscopy methods to study normal mouse lung tissue and also after subcutaneous transplantation of a B-16 melanoma tumor in the tissue. We also studied tissues with B-16 melanoma after they were treated with coordination compounds based on palladium complexes of methylenediphosphonic acid. The IR spectra of the lung tissues with metastases in the region of the C = O stretching vibrations are different from the IR spectra of normal tissue. We identified spectroscopic signs of the presence of metastases in the lung. We show that when a cancerous tumor is treated with a preparation of palladium complexes of methylenediphosphonic acid, the spectroscopic signs of the presence of metastases in the lung are missing. After treatment with the optimal dose of this drug, the IR spectrum of the lung tissue in which multiple metastases were present before treatment corresponds to the spectrum of normal tissue. We have determined the efficacy of the antitumor activity of coordination compounds based on palladium complexes of methylenediphosphonic acid.
Similar content being viewed by others
References
R. A. Shaw and H. H. Mantsch, J. Mol. Struct., 480/481, 1–13 (1999).
J. M. Chalmer and P. R. Griffiths, eds., Handbook of Vibrational Spectroscopy: Application in Life, Pharmaceutical and Natural Sciences, Vol. 5, Wiley, New York (2002).
Z. Movasaghi, Sh. Rehman, and I. Rehman, Appl. Spectr. Rev., 43, No. 2, 134–179 (2008).
J. Dubois and R. A. Shaw, Anal. Chem., 76, No. 19, 360A–367A (2004).
R. K. Sahy and S. Mordechai, Future Oncology, I, No. 5, 635–647 (2005).
G. B. Tolstorozhev, I. V. Skornyakov, and V. A. Butra, Zh. Prikl. Spektrosk., 76, No. 6, 805–816 (2009).
G. B. Tolstorozhev, I. V. Skornyakov, and V. A. Butra, Zh. Prikl. Spektrosk., 77, No. 3, 460–464 (2010).
M. M. Zolotukhina, V. I. Krutikov, and A. N. Lavrent’ev, Usp. Khim., 62, No. 7, 691–703 (1993).
K. P. Balitskii, A. L. Vorontsova, and I. A. Lisnyak, Metastasis of Tumors: Pathogenetic Aspects [in Russian], Naukova Dumka (1991).
Yu. I. Kudryavets’, "Interferon and tumor necrosis factor as modifiers of metastasis of malignant neoplasms," Dissertation in competition for the academic degree of Doctor of Biological Sciences, Kiev (1999).
V. B. Prozorovskii, Toksikolog. Vestn., No. 1, 28–32 (1998).
A. S. Krylov, A. N. Vtyurin, and Yu. V. Gerasimova, "Treatment of Fourier transform infrared spectroscopy data. Technical Manual", Preprint No. 832 F, Inst. Fiziki SO RAN, Krasnoyarsk (2005).
I. V. Skornyakov, G. B. Tolstorozhev, and V. A. Butra, Zh. Prikl. Spektrosk., 75, No. 3, 395–399 (2008).
I. V. Skornyakov, G. B. Tolstorozhev, and V. A. Butra, Zh. Prikl. Spektrosk., 76, No. 2, 261–266 (2009).
J. Kong and Sh. Yu, Acta Biochim. Biophys. Sinica, 39, No. 8, 549–559 (2007).
B. R. Singh, ed., Infrared Analysis of Peptides and Proteins: Principles and Application, American Chemical Society (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 79, No. 3, pp. 471–476, May–June, 2012.
Rights and permissions
About this article
Cite this article
Tolstorozhev, G.B., Skornyakov, I.V., Pekhnio, V.I. et al. Signs of antimetastatic activity of palladium complexes of methylenediphosphonic acid in IR spectra. J Appl Spectrosc 79, 453–458 (2012). https://doi.org/10.1007/s10812-012-9622-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10812-012-9622-2