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Treatment of massive subretinal hematoma associated with age-related macular degeneration using vitrectomy with intentional giant tear

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Abstract

The purpose of this study was to report the surgical outcomes after creating a 120° intentional giant retinal tear for use in removing hemorrhage and subretinal proliferative tissue in patients with polypoidal choroidal vasculopathy (PCV) or age-related macular degeneration (ARMD). This study involved 12 eyes of 12 patients (10 eyes: PCV, 2 eyes: ARMD). After removal of the lens in phakic eyes, we performed a vitrectomy with artificial posterior vitreous detachment. Subsequently, a 120° intentional giant retinal tear was created in the temporal periphery, the retina was then turned, and the subretinal hemorrhage and proliferative tissue were removed. In order to preserve as much of the retinal pigment epithelium (RPE) as possible, we used a bimanual technique under direct visualization. After stretching the retina by use of perfluorocarbon liquid (PFCL), we performed endophotocoagulation around the tear followed by PFCL/silicone oil exchange. Except for 1 eye in which extensive loss of the RPE occurred, the fundus findings and the visual acuity (VA) improved in all patients. In addition, postoperative VA improved to ≥20/50 in 3 eyes in which the macular RPE was preserved. This surgical procedure is an effective treatment for PCV or ARMD patients with extensive subretinal hemorrhage and proliferative tissue.

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References

  1. Ohji M, Saito Y, Hayashi A, Lewis JM, Tano Y (1998) Pneumatic displacement of subretinal hemorrhage without tissue plasminogen activator. Arch Ophthalmol 116(10):1326–1332

    Article  CAS  PubMed  Google Scholar 

  2. Gopalakrishan M, Giridhar A, Bhat S, Saikumar SJ, Elias A, N S (2007) Pneumatic displacement of submacular hemorrhage: safety, efficacy, and patient selection. Retina 27(3):329–334

    Article  PubMed  Google Scholar 

  3. Hesse L, Schmidt J, Kroll P (1999) Management of acute submacular hemorrhage using recombinant tissue plasminogen activator and gas. Graefes Arch Clin Exp Ophthalmol 237(4):273–277

    Article  CAS  PubMed  Google Scholar 

  4. Hassan AS, Johnson MW, Schneiderman TE, Regillo CD, Tornambe PE, Poliner LS, Blodi BA, Elner SG (1999) Management of submacular hemorrhage with intravitreous tissue plasminogen activator injection and pneumatic displacement. Ophthalmology 106(10):1900–1906

    Article  CAS  PubMed  Google Scholar 

  5. Hattenbach LO, Klais C, Koch FH, Gümbel HO (2001) Intravitreous injection of tissue plasminogen activator and gas in the treatment of submacular hemorrhage under various conditions. Ophthalmology 108(8):1485–1492

    Article  CAS  PubMed  Google Scholar 

  6. Haupert CL, McCuen BW 2nd, Jaffe GJ, Steuer ER, Cox TA, Toth CA, Fekrat S, Postel EA (2001) Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration. Am J Ophthalmol 131(2):208–215

    Article  CAS  PubMed  Google Scholar 

  7. Olivier S, Chow DR, Packo KH, MacCumber MW, Awh CC (2004) Subretinal recombinant tissue plasminogen activator injection and pneumatic displacement of thick submacular hemorrhage in age-related macular degeneration. Ophthalmology 111(6):1201–1208

    Article  PubMed  Google Scholar 

  8. Singh RP, Patel C, Sears JE (2006) Management of subretinal macular haemorrhage by direct administration of tissue plasminogen activator. Br J Ophthalmol 90(4):429–431

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kamei M, Tano Y, Maeno T, Ikuno Y, Mitsuda H, Yuasa T (1996) Surgical removal of submacular hemorrhage using tissue plasminogen activator and perfluorocarbon liquid. Am J Ophthalmol 121(3):267–275

    Article  CAS  PubMed  Google Scholar 

  10. Tilanus MA, Vaandrager W, Cuypers MH, Verbeek AM, Hoyng CB (2000) Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 238(6):482–485

    Article  CAS  PubMed  Google Scholar 

  11. Oshima Y, Ohji M, Tano Y (2007) Pars plana vitrectomy with peripheral retinotomy after injection of preoperative intravitreal tissue plasminogen activator: a modified procedure to drain massive subretinal haemorrhage. Br J Ophthalmol 91(2):193–198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Krebs I, Brannath W, Glittenberg C, Zeiler F, Sebag J, Binder S (2007) Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Am J Ophthalmol 144(5):741–746

    Article  PubMed  Google Scholar 

  13. Robison CD, Krebs I, Binder S, Barbazetto IA, Kotsolis AI, Yannuzzi LA, Sadun AA, Sebag J (2009) Vitreomacular adhesion in active and end-stage age-related macular degeneration. Am J Ophthalmol 148(1):79–82

    Article  PubMed  Google Scholar 

  14. Schulze S, Hoerle S, Mennel S, Kroll P (2008) Vitreomacular traction and exudative age-related macular degeneration. Acta Ophthalmol 86(5):470–481

    Article  PubMed  Google Scholar 

  15. Green-Simms AE, Bakri SJ (2011) Vitreomacular traction and age-related macular degeneration. Semin Ophthalmol 26(3):137–138

    Article  PubMed  Google Scholar 

  16. Ikeda T, Sawa H, Koizumi K, Yasuhara T, Yamasaki T (2000) Pars plana vitrectomy for regression of choroidal neovascularization with age-related macular degeneration. Acta Ophthalmol Scand 78(4):460–464

    Article  CAS  PubMed  Google Scholar 

  17. van Meurs JC, ter Averst E, Hofland LJ, van Hagen PM, Mooy CM, Baarsma GS, Kuijpers RW, Boks T, Stalmans P (2004) Autologous peripheral retinal pigment epithelium translocation in patients with subfoveal neovascular membranes. Br J Ophthalmol 88(1):110–113

    Article  PubMed  PubMed Central  Google Scholar 

  18. van Zeeburg EJ, Maaijwee KJ, Missotten TO, Heimann H, van Meurs JC (2012) A free retinal pigment epithelium-choroid graft in patients with exudative age-related macular degeneration: results up to 7 years. Am J Ophthalmol 153(1):120–127

    Article  PubMed  Google Scholar 

  19. Kamao H, Mandai M, Okamoto S, Sakai N, Suga A, Sugita S, Kiryu J, Takahashi M (2014) Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Rep 2(2):205–218

    Article  CAS  Google Scholar 

  20. Kanemura H, Go MJ, Shikamura M, Nishishita N, Sakai N, Kamao H, Mandai M, Morinaga C, Takahashi M, Kawamata S (2014) Tumorigenicity studies of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of age-related macular degeneration. PLoS One 9(1):e85336

    Article  PubMed  PubMed Central  Google Scholar 

  21. Jin ZB, Okamoto S, Mandai M, Takahashi M (2009) Induced pluripotent stem cells for retinal degenerative diseases: a new perspective on the challenges. J Genet 88(4):417–424

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors wish to thank John Bush for reviewing the manuscript.

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Correspondence to Tsunehiko Ikeda.

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Isizaki, E., Morishita, S., Sato, T. et al. Treatment of massive subretinal hematoma associated with age-related macular degeneration using vitrectomy with intentional giant tear. Int Ophthalmol 36, 199–206 (2016). https://doi.org/10.1007/s10792-015-0102-6

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  • DOI: https://doi.org/10.1007/s10792-015-0102-6

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