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Retinal pigment epithelial tear after intravitreal ranibizumab for subfoveal CNV secondary to AMD

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Abstract

Purpose

To report a case of retinal pigment epithelial tear following intravitreal ranibizumab injection for subfoveal choroidal neovascularization.

Methods

Retrospective single case review.

Results

A 78-year-old Caucasian female was treated with intravitreal ranibizumab for occult subfoveal choroidal neovascularization (CNV) from age-related macular degeneration (AMD). She returned for evaluation with decreased vision and was found to have a retinal pigment epithelial tear on biomicroscopy. Fluorescein angiography and OCT testing confirmed the clinical findings.

Conclusion

Although a pigment epithelial tear in neovascular AMD can represent natural history, prior reports of such tears after thermal laser, photodynamic therapy with verteporfin and following intravitreal injection of pegaptanib Na combined with this case report suggest that clinicians should be aware of and monitor patients for the possibility of this complication after intravitreal injections of ranibizumab.

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References

  1. Gass JD (1984) Retinal pigment epithelial rip during krypton red laser photocoagulation. Am J Ophthalmol 98(6):700–706

    PubMed  CAS  Google Scholar 

  2. Gelisken F, Inhoffen W, Partsch M, Schneider U, Kreissig I (2001) Retinal pigment epithelial tear after photodynamic therapy for choroidal neovascularization. Am J Ophthalmol 131(4):518–520

    Article  PubMed  CAS  Google Scholar 

  3. Dhalla MS, Blinder KJ, Tewari A, Hariprasad SM, Apte RS (2006) Retinal pigment epithelial tear following intravitreal pegaptanib sodium. Am J Ophthalmol 141(4):752–754

    Article  PubMed  CAS  Google Scholar 

  4. Gass JD (1984) Pathogenesis of tears of the retinal pigment epithelium. Br J Ophthalmol 68(8):513–519

    PubMed  CAS  Google Scholar 

  5. Shah CP, Hsu J, Garg SJ, Fischer DH, Kaiser R (2006) Retinal pigment epithelial tear after intravitreal bevacizumab injection. Am J Ophthalmol 142(6):1070–1072

    Article  PubMed  CAS  Google Scholar 

  6. Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S (2006) Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355(14):1432–1444

    Article  PubMed  CAS  Google Scholar 

  7. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355(14):1419–1431

    Article  PubMed  CAS  Google Scholar 

  8. Coscas G, Koenig F, Soubrane G (1990) The pretear characteristics of pigment epithelial detachments. A study of 40 eyes. Arch Ophthalmol 108(12):1687–1693

    PubMed  CAS  Google Scholar 

  9. Krishan NR, Chandra SR, Stevens TS (1985) Diagnosis and pathogenesis of retinal pigment epithelial tears. Am J Ophthalmol 100(5):698–707

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St. Louis, MO, 63110, USA

    Rajendra S. Apte

  2. Barnes Retina Institute, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Rajendra S. Apte

Authors
  1. Rajendra S. Apte
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Correspondence to Rajendra S. Apte.

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Apte, R.S. Retinal pigment epithelial tear after intravitreal ranibizumab for subfoveal CNV secondary to AMD. Int Ophthalmol 27, 59–61 (2007). https://doi.org/10.1007/s10792-007-9066-5

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  • DOI: https://doi.org/10.1007/s10792-007-9066-5

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