Abstract
The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovered in bronchoalveolar lavage fluid, and increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that AG substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model. Our findings support the possible use of AG as a therapeutic drug for patients with allergic asthma.
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Liu, J., Cheng, Y., Zhang, X. et al. Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model. Inflammation 38, 2007–2016 (2015). https://doi.org/10.1007/s10753-015-0181-6
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DOI: https://doi.org/10.1007/s10753-015-0181-6