Skip to main content

Advertisement

SpringerLink
Log in

Clinical correlates and pharmacological management of Asian patients with concomitant diabetes mellitus and heart failure

  • Published:
Heart Failure Reviews Aims and scope Submit manuscript

Abstract

Asia is the center of convergence of the twin epidemics of diabetes mellitus (DM) and heart failure (HF). The regional and ethnic diversity across Asia, along with a high prevalence of a young, lean diabetic phenotype, emphasizes the importance of targeted public health strategies that address the unique needs of Asian patients with DM and HF. This review discusses the epidemiology, clinical correlates, pharmacological management, and outcomes of Asian patients with concomitant DM and HF.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Omran AR (2005) The epidemiologic transition: a theory of the epidemiology of population change. 1971. Milbank Q 83(4):731–757. https://doi.org/10.1111/j.1468-0009.2005.00398.x

    Article  PubMed  PubMed Central  Google Scholar 

  2. World population ageing 2015 (2015) United Nations. http://www.un.org/en/development/desa/population/theme/ageing/WPA2015.shtml. Accessed 26 June 2017

  3. Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB (2009) Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 301(20):2129–2140. https://doi.org/10.1001/jama.2009.726

    Article  CAS  PubMed  Google Scholar 

  4. Dans A, Ng N, Varghese C, Tai ES, Firestone R, Bonita R (2011) The rise of chronic non-communicable diseases in southeast Asia: time for action. Lancet 377(9766):680–689. https://doi.org/10.1016/S0140-6736(10)61506-1

    Article  PubMed  Google Scholar 

  5. Ramachandran A, Ma RC, Snehalatha C (2010) Diabetes in Asia. Lancet 375(9712):408–418. https://doi.org/10.1016/S0140-6736(09)60937-5

    Article  PubMed  Google Scholar 

  6. Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE, Makaroff LE (2017) IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 128:40–50. https://doi.org/10.1016/j.diabres.2017.03.024

    Article  CAS  PubMed  Google Scholar 

  7. WHO (2017) Cardiovascular diseases World Health Organization. http://wwwwhoint/mediacentre/factsheets/fs317/en/ Accessed 15 July 2017

  8. IDF Diabetes Atlas (2015) International Diabetes Federation

  9. De Groote P, Lamblin N, Mouquet F, Plichon D, McFadden E, Van Belle E, Bauters C (2004) Impact of diabetes mellitus on long-term survival in patients with congestive heart failure. Eur Heart J 25(8):656–662. https://doi.org/10.1016/j.ehj.2004.01.010

    Article  PubMed  Google Scholar 

  10. Lam CSP (2015) Heart failure in Southeast Asia: facts and numbers. ESC Heart Fail 2(2):46–49. https://doi.org/10.1002/ehf2.12036

    Article  PubMed  Google Scholar 

  11. Lam CS, Teng TK, Tay WT, Anand I, Zhang S, Shimizu W, Narasimhan C, Park SW, Yu CM, Ngarmukos T, Omar R, Reyes EB, Siswanto BB, Hung CL, Ling LH, Yap J, MacDonald M, Richards AM (2016) Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry. Eur Heart J 37(41):3141–3153. https://doi.org/10.1093/eurheartj/ehw331

    Article  PubMed  Google Scholar 

  12. Sakata Y, Shimokawa H (2013) Epidemiology of heart failure in Asia. Circ J 77(9):2209–2217. https://doi.org/10.1253/circj.CJ-13-0971

    Article  PubMed  Google Scholar 

  13. Hu FB (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 34(6):1249–1257. https://doi.org/10.2337/dc11-0442

    Article  PubMed  PubMed Central  Google Scholar 

  14. Misra A, Ramchandran A, Jayawardena R, Shrivastava U, Snehalatha C (2014) Diabetes in South Asians. Diabet Med 31(10):1153–1162. https://doi.org/10.1111/dme.12540

    Article  CAS  PubMed  Google Scholar 

  15. Ma RC, Chan JC (2013) Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci 1281(1):64–91. https://doi.org/10.1111/nyas.12098

    Article  PubMed  PubMed Central  Google Scholar 

  16. Nanditha A, Ma RCW, Ramachandran A, Snehalatha C, Chan JCN, Chia KS, Shaw JE, Zimmet PZ (2016) Diabetes in Asia and the Pacific: implications for the global epidemic. Diabetes Care 39(3):472–485. https://doi.org/10.2337/dc15-1536

    Article  CAS  PubMed  Google Scholar 

  17. Hu SS, Kong LZ, Gao RL, Zhu ML, Wang W, Wang YJ, Wu ZS, Chen WW, Liu MB (2012) Outline of the report on cardiovascular disease in China, 2010. Biomed Environ Sci 25(3):251–256. https://doi.org/10.3967/0895-3988.2012.03.001

    PubMed  Google Scholar 

  18. Bank IEM, Gijsberts CM, Teng T-HK, Benson L, Sim D, Yeo PSD, Ong HY, Jaufeerally F, Leong GKT, Ling LH, Richards AM, de Kleijn DPV, Dahlström U, Lund LH, Lam CSP (2017) Prevalence and clinical significance of diabetes in Asian versus White patients with heart failure. JACC Heart Fail 5(1):14–24. https://doi.org/10.1016/j.jchf.2016.09.015

    Article  PubMed  Google Scholar 

  19. Takeuchi T, Nakao M, Nomura K, Yano E (2009) Association of metabolic syndrome with depression and anxiety in Japanese men. Diabetes Metab 35(1):32–36. https://doi.org/10.1016/j.diabet.2008.06.006

    Article  CAS  PubMed  Google Scholar 

  20. Ramachandran A, Snehalatha C, Ma RC (2014) Diabetes in South-East Asia: an update. Diabetes Res Clin Pract 103(2):231–237. https://doi.org/10.1016/j.diabres.2013.11.011

    Article  PubMed  Google Scholar 

  21. Whiting DR, Guariguata L, Weil C, Shaw J (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94(3):311–321. https://doi.org/10.1016/j.diabres.2011.10.029

    Article  PubMed  Google Scholar 

  22. Forouhi NG, Merrick D, Goyder E, Ferguson BA, Abbas J, Lachowycz K, Wild SH (2006) Diabetes prevalence in England, 2001—estimates from an epidemiological model. Diabet Med 23(2):189–197. https://doi.org/10.1111/j.1464-5491.2005.01787.x

    Article  CAS  PubMed  Google Scholar 

  23. Ramachandran A, Snehalatha C, Shetty AS, Nanditha A (2012) Trends in prevalence of diabetes in Asian countries. World J Diabetes 3(6):110–117. https://doi.org/10.4239/wjd.v3.i6.110

    Article  PubMed  PubMed Central  Google Scholar 

  24. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB, American Heart Association Statistics C, Stroke Statistics S (2015) Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation 131(4):e29–322. https://doi.org/10.1161/CIR.0000000000000152

    Article  PubMed  Google Scholar 

  25. Chaturvedi V, Parakh N, Seth S, Bhargava B, Ramakrishnan S, Roy A, Saxena A, Gupta N, Misra P, Rai S, Anand K, Pandav C, Sharma R, Prasad S (2016) Heart failure in India: the INDUS (INDia Ukieri Study) study. J Pract Cardiovasc Sci 2(1):28–35. https://doi.org/10.4103/2395-5414.182988

    Article  Google Scholar 

  26. Okamoto H, Kitabatake A (2003) The epidemiology of heart failure in Japan. Nihon Rinsho 61(5):709–714

    PubMed  Google Scholar 

  27. Rhee E-J (2015) Diabetes in Asians. Endocrinol Metab 30(3):263–269. https://doi.org/10.3803/EnM.2015.30.3.263

    Article  CAS  Google Scholar 

  28. Ramachandran A, Chamukuttan S, Shetty SA, Arun N, Susairaj P (2012) Obesity in Asia—is it different from rest of the world. Diabetes Metab Res Rev 28(Suppl 2):47–51. https://doi.org/10.1002/dmrr.2353

    Article  PubMed  Google Scholar 

  29. Rajadurai J, Tse H-F, Wang C-H, Yang N-I, Zhou J, Sim D (2017) Understanding the epidemiology of heart failure to improve management practices: an Asia-Pacific perspective. J Cardiac Fail 23(4):327–339. https://doi.org/10.1016/j.cardfail.2017.01.004

    Article  Google Scholar 

  30. Teng T, Tay W, Yap J, Anand I, Zhang S, Shimizu W, Narasimhan C, Park S, Yu C, Ngarmukos T, Omar R, Reyes E, Siswanto B, Hung C, Ling L, Richards A, Lam C (2017) Ethnic and regional variation in diabetes among Asian patients with heart failure. Eur J Heart Fail 37:736

    Google Scholar 

  31. Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, Palileo-Villaneuva L, Lopez-Jaramillo P, Karaye K, Yusoff K, Orlandini A, Sliwa K, Mondo C, Lanas F, Prabhakaran D, Badr A, Elmaghawry M, Damasceno A, Tibazarwa K, Belley-Cote E, Balasubramanian K, Islam S, Yacoub MH, Huffman MD, Harkness K, Grinvalds A, McKelvie R, Bangdiwala SI, Yusuf S, Campos R, Chacón C, Cursack G, Diez F, Escobar C, Garcia C, Vilamajo OG, Hominal M, Ingaramo A, Kucharczuk G, Pelliza M, Rojas A, Villani A, Zapata G, Bourke P, Lanas F, Nahuelpan L, Olivares C, Riquelme R, Ai F, Bai X, Chen X, Chen Y, Gao M, Ge C, He Y, Huang W, Jiang H, Liang T, Liang X, Liao Y, Liu S, Luo Y, Lu L, Qin S, Tan G, Tan H, Wang T, Wang X, Wei F, Xiao F, Zhang B, Zheng T, Mendoza JLA, Anaya MB, Gomez E, de Salazar DIM, Quiroz F, Rodríguez MJ, Sotomayor MS, Navas AT, León MB, Montalvo LAF, Jaramillo ML, Patiño EP, Perugachi C, Trujillo Cruz F, Elmaghawry M, Wagdy K, Bhardwaj AK, Chaturvedi V, Gokhale GK, Gupta R, Honnutagi R, Joshi P, Ladhani S, Negi PC, Roy A, Reddy N, Abdullah A, Hassan MRA, Balasinga M, Kasim S, Tan WY, Yusoff K, Damasceno A, Banze R, Calua E, Novela C, Chemane J, Akintunde AA, Ansa V, Gbadamosi H, Karaye KM, Mbakwem A, Mohammed S, Nwafor E, Ojji D, Olunuga T, Sa'idu BOH, Umuerri E, Alcaraz J, Palileo-Villanueva L, Palomares E, Timonera MR, Badr A, Alghamdi S, Alhabib K, Almasood A, Alsaif S, Elasfar A, Ghabashi A, Mimish L, Bester F, Kelbe D, Klug E, Sliwa K, Tibarzawa K, Abdalla OE, Dimitri ME, Mustafa H, Osman O, Saad A, Mondo C (2017) Global mortality variations in patients with heart failure: results from the International Congestive Heart Failure (INTER-CHF) prospective cohort study. Lancet Glob Health 5(7):e665–e672. https://doi.org/10.1016/S2214-109X(17)30196-1

    Article  PubMed  Google Scholar 

  32. Guo Y, Lip GYH, Banerjee A (2013) Heart failure in East Asia. Curr Cardiol Rev 9(2):112–122. https://doi.org/10.2174/1573403X11309020004

    Article  PubMed  PubMed Central  Google Scholar 

  33. Sellayah D, Cagampang FR, Cox RD (2014) On the evolutionary origins of obesity: a new hypothesis. Endocrinology 155(5):1573–1588. https://doi.org/10.1210/en.2013-2103

    Article  PubMed  Google Scholar 

  34. Tillin T, Hughes AD, Mayet J, Whincup P, Sattar N, Forouhi NG, McKeigue PM, Chaturvedi N (2013) The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited)—a prospective population-based study. J Am Coll Cardiol 61(17):1777–1786. https://doi.org/10.1016/j.jacc.2012.12.046

    Article  PubMed  PubMed Central  Google Scholar 

  35. Shah A, Kanaya AM (2014) Diabetes and associated complications in the South Asian population. Curr Cardiol Rep 16(5):476–476. https://doi.org/10.1007/s11886-014-0476-5

    Article  PubMed  PubMed Central  Google Scholar 

  36. Pardhan S, Gilchrist J, Mahomed I (2004) Impact of age and duration on sight-threatening retinopathy in South Asians and Caucasians attending a diabetic clinic. Eye (London, England) 18(3):233–240. https://doi.org/10.1038/sj.eye.6700629

    Article  CAS  Google Scholar 

  37. Dixon AN, Raymond NT, Mughal S, Rahim A, O'Hare JP, Kumar S, Barnett AH (2006) Prevalence of microalbuminuria and hypertension in South Asians and white Europeans with type 2 diabetes: a report from the United Kingdom Asian Diabetes Study (UKADS). Diab Vasc Dis Res 3(1):22–25. https://doi.org/10.3132/dvdr.2006.002

    Article  PubMed  Google Scholar 

  38. Chandie Shaw PK, Baboe F, van Es LA, van der Vijver JC, van de Ree MA, de Jonge N, Rabelink TJ (2006) South-Asian type 2 diabetic patients have higher incidence and faster progression of renal disease compared with Dutch-European diabetic patients. Diabetes Care 29(6):1383–1385. https://doi.org/10.2337/dc06-0003

    Article  PubMed  Google Scholar 

  39. Dreyer G, Hull S, Aitken Z, Chesser A, Yaqoob MM (2009) The effect of ethnicity on the prevalence of diabetes and associated chronic kidney disease. QJM 102(4):261–269. https://doi.org/10.1093/qjmed/hcn177

    Article  CAS  PubMed  Google Scholar 

  40. Teng T, Tay W, Yan L, Tromp J, Anand I, Richards A, Yap J, Macdonald M, Ling L, Siswanto B, Liew H, Reyes E, Shimizu W, Zhang S, Narasimhan C, Yu C, Park S, Ngarmukos T, Hung C, Regensteiner J, Lam C (2017) Sex differences in diabetic patients from the ASIAN-HF registry. Eur J Heart Fail 19:470–470

    Google Scholar 

  41. Cockram CS (2000) The epidemiology of diabetes mellitus in the Asia-Pacific region. Hong Kong Med J 6(1):43–52

    CAS  PubMed  Google Scholar 

  42. Abate N, Chandalia M (2007) Ethnicity, type 2 diabetes & migrant Asian Indians. Indian J Med Res 125(3):251–258

    PubMed  Google Scholar 

  43. Abate N, Chandalia M, Snell PG, Grundy SM (2004) Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men. J Clin Endocrinol Metab 89(6):2750–2755. https://doi.org/10.1210/jc.2003-031843

    Article  CAS  PubMed  Google Scholar 

  44. McKeigue PM, Pierpoint T, Ferrie JE, Marmot MG (1992) Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in South Asians and Europeans. Diabetologia 35(8):785–791. https://doi.org/10.1007/BF00429101

    CAS  PubMed  Google Scholar 

  45. Barma P, Ranabir S, Prasad L, Singh T (2011) Clinical and biochemical profile of lean type 2 diabetes mellitus. Indian J Endocrinol Metabol 15(5):40–43. https://doi.org/10.4103/2230-8210.83061

    Article  Google Scholar 

  46. Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444(7121):840–846. https://doi.org/10.1038/nature05482

    Article  CAS  PubMed  Google Scholar 

  47. Deurenberg-Yap M, Chew SK, Deurenberg P (2002) Elevated body fat percentage and cardiovascular risks at low body mass index levels among Singaporean Chinese, Malays and Indians. Obes Rev 3(3):209–215. https://doi.org/10.1046/j.1467-789X.2002.00069.x

    Article  CAS  PubMed  Google Scholar 

  48. Gustafsson I, Brendorp B, Seibaek M, Burchardt H, Hildebrandt P, Kober L, Torp-Pedersen C, Danish Investigatord of A, Mortality on Dofetilde Study G (2004) Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure. J Am Coll Cardiol 43(5):771–777. https://doi.org/10.1016/j.jacc.2003.11.024

    Article  PubMed  Google Scholar 

  49. MacDonald MR, Jhund PS, Petrie MC, Lewsey JD, Hawkins NM, Bhagra S, Munoz N, Varyani F, Redpath A, Chalmers J, MacIntyre K, McMurray JJ (2008) Discordant short- and long-term outcomes associated with diabetes in patients with heart failure: importance of age and sex: a population study of 5.1 million people in Scotland. Circ Heart Fail 1(4):234–241. https://doi.org/10.1161/circheartfailure.108.794008

    Article  PubMed  Google Scholar 

  50. Mosterd A, Cost B, Hoes AW, de Bruijne MC, Deckers JW, Hofman A, Grobbee DE (2001) The prognosis of heart failure in the general population: the Rotterdam study. Eur Heart J 22(15):1318–1327. https://doi.org/10.1053/euhj.2000.2533

    Article  CAS  PubMed  Google Scholar 

  51. Pocock SJ, Wang D, Pfeffer MA, Yusuf S, McMurray JJ, Swedberg KB, Ostergren J, Michelson EL, Pieper KS, Granger CB (2006) Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J 27(1):65–75. https://doi.org/10.1093/eurheartj/ehi555

    Article  PubMed  Google Scholar 

  52. Domanski M, Krause-Steinrauf H, Deedwania P, Follmann D, Ghali JK, Gilbert E, Haffner S, Katz R, Lindenfeld J, Lowes BD, Martin W, McGrew F, Bristow MR, Investigators B (2003) The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial. J Am Coll Cardiol 42(5):914–922. https://doi.org/10.1016/S0735-1097(03)00856-8

    Article  PubMed  Google Scholar 

  53. Suskin N, McKelvie RS, Burns RJ, Latini R, Pericak D, Probstfield J, Rouleau JL, Sigouin C, Solymoss CB, Tsuyuki R, White M, Yusuf S (2000) Glucose and insulin abnormalities relate to functional capacity in patients with congestive heart failure. Eur Heart J 21(16):1368–1375. https://doi.org/10.1053/euhj.1999.2043

    Article  CAS  PubMed  Google Scholar 

  54. Kaneko H, Suzuki S, Goto M, Arita T, Yuzawa Y, Yagi N, Murata N, Kato Y, Kano H, Matsuno S, Otsuka T, Uejima T, Oikawa Y, Sagara K, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yajima J, Yamashita T (2015) Incidence and predictors of rehospitalization of acute heart failure patients. Int Heart J 56(2):219–225. https://doi.org/10.1536/ihj.14-290

    Article  PubMed  Google Scholar 

  55. Lee R, Chan S-P, Wong J, Lau D, Ho K-T, Ng K (2010) Impact of diabetes mellitus on survival in South East Asian patients with congestive heart failure due to left ventricular systolic dysfunction. Int J Cardiol 142(1):97–100. https://doi.org/10.1016/j.ijcard.2008.11.139

    Article  PubMed  Google Scholar 

  56. Huxley RR, Barzi F, Woo J, Giles G, Lam TH, Rahimi K, Konety S, Ohkubo T, Jee SH, Fang X, Woodward M (2014) A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: an overview of individual participant data from 32 prospective cohorts from the Asia-Pacific region. BMC Cardiovasc Disord 14(1):61. https://doi.org/10.1186/1471-2261-14-61

    Article  PubMed  PubMed Central  Google Scholar 

  57. Marathe PH, Gao HX, Close KL (2017) American Diabetes Association Standards of Medical Care in Diabetes 2017. J Diabetes 9(4):320–324. https://doi.org/10.1111/1753-0407.12524

    Article  PubMed  Google Scholar 

  58. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P (2016) 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 18(8):891–975. https://doi.org/10.1002/ejhf.592

    Article  PubMed  Google Scholar 

  59. Ko S-H, Kim D-J, Park J-H, Park C-Y, Jung CH, Kwon H-S, Park J-Y, Song K-H, Han K, Lee K-U, Ko K-S (2016) Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013: nationwide population-based cohort study. Medicine 95(27):e4018. https://doi.org/10.1097/MD.0000000000004018

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Ou HT, Chang KC, Liu YM, Wu JS (2017) Recent trends in the use of antidiabetic medications from 2008 to 2013: a nation-wide population-based study from Taiwan. J Diabetes 9(3):256–266. https://doi.org/10.1111/1753-0407.12408

    Article  PubMed  Google Scholar 

  61. Chia Y, T T, Tay W, Tromp J, Richards A, Ling L, Shimizu W, Park S, Hung C, Ngarmukos T, Liew H, Zhang S, Narasimhan C, Siswanto B, Reyes E, Yu C, Anand I, Yap J, Macdonald M, Lam C (2017) Prescription of anti-diabetic-glucose-lowering agents and clinical outcomes in asian patients with heart failure and type 2 diabetes mellitus. Eur J Heart Fail 19:292–292

    Google Scholar 

  62. Fitchett D, Zinman B, Wanner C, Lachin JM, Hantel S, Salsali A, Johansen OE, Woerle HJ, Broedl UC, Inzucchi SE (2016) Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial. Eur Heart J 37(19):1526–1534. https://doi.org/10.1093/eurheartj/ehv728

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Kaku K, Lee J, Mattheus M, Kaspers S, George J, Woerle H-J, on behalf of the E-REGOI (2017) Empagliflozin and cardiovascular outcomes in Asian patients with type 2 diabetes and established cardiovascular disease―results from EMPA-REG OUTCOME®―. Circ J 81(2):227–234. https://doi.org/10.1253/circj.CJ-16-1148

    Article  PubMed  Google Scholar 

  64. Fung CSC, Wan EYF, Wong CKH, Jiao F, Chan AKC (2015) Effect of metformin monotherapy on cardiovascular diseases and mortality: a retrospective cohort study on Chinese type 2 diabetes mellitus patients. Cardiovasc Diabetol 14(1):137. https://doi.org/10.1186/s12933-015-0304-2

    Article  PubMed  PubMed Central  Google Scholar 

  65. Kankanala SR, Syed R, Gong Q, Ren B, Rao X, Zhong J (2016) Cardiovascular safety of dipeptidyl peptidase-4 inhibitors: recent evidence on heart failure. Am J Transl Res 8(5):2450–2458

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Hippisley-Cox J, Coupland C (2016) Diabetes treatments and risk of heart failure, cardiovascular disease, and all cause mortality: cohort study in primary care. BMJ 354. https://doi.org/10.1136/bmj.i3477

Download references

Funding

The ASIAN-HF study is supported by grants from National Medical Research Council of Singapore, A*STAR Biomedical Research Council ATTRaCT program, Boston Scientific Investigator Sponsored Research Program, and Bayer. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation.

Author information

Authors and Affiliations

  1. Duke-NUS Medical School, Singapore, Singapore

    Yvonne May Fen Chia & Carolyn S. P. Lam

  2. National Heart Centre Singapore, Singapore, Singapore

    Tiew-Hwa Katherine Teng, Chanchal Chandramouli, Jonathan Yap & Carolyn S. P. Lam

  3. School of Population and Global Health, University of Western Australia, Crawley, Australia

    Tiew-Hwa Katherine Teng

  4. Changi General Hospital, Singapore, Singapore

    Michael MacDonald

  5. Cardiovascular Research Institute, National University Heart Centre, Singapore, Singapore

    Carolyn S. P. Lam

Authors
  1. Yvonne May Fen Chia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tiew-Hwa Katherine Teng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chanchal Chandramouli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jonathan Yap
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Michael MacDonald
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Carolyn S. P. Lam
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carolyn S. P. Lam.

Ethics declarations

Conflict of interest

Dr. Lam has no relevant disclosure for the present work.

Unrelated to present work: Research support or grants from National Medical Research Council of Singapore, non-financial support from Boston Scientific, non-financial support from Bayer, non-financial support from Thermofisher, non-financial support from Vifor Pharma, other from Bayer, other from Novartis, other from Takeda, other from Merck, other from Astra Zeneca, other from Janssen Research & Development, other from LLC, other from Menarini, other from Boehringer Ingelheim, other from Abbott Diagnostics, from DC Devices, outside the submitted work; in addition, Dr. Lam has a patent PCT/SG2016/050217 pending.

Dr. Chia, Dr. Teng, Dr. Chandramouli, Dr. Yap, and Dr. MacDonald declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chia, Y.M.F., Teng, TH.K., Chandramouli, C. et al. Clinical correlates and pharmacological management of Asian patients with concomitant diabetes mellitus and heart failure. Heart Fail Rev 23, 461–468 (2018). https://doi.org/10.1007/s10741-018-9672-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10741-018-9672-5

Keywords

Search

Navigation