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Peripheral vascular function, oxygen delivery and utilization: the impact of oxidative stress in aging and heart failure with reduced ejection fraction

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Abstract

The aging process appears to be a precursor to many age-related diseases, perhaps the most impactful of which is cardiovascular disease (CVD). Heart disease, a manifestation of CVD, is the leading cause of death in the USA, and heart failure (HF), a syndrome that develops as a consequence of heart disease, now affects almost six million American. Importantly, as this is an age-related disease, this number is likely to grow along with the ever-increasing elderly population. Hallmarks of the aging process and HF patients with a reduced ejection fraction (HFrEF) include exercise intolerance, premature fatigue, and limited oxygen delivery and utilization, perhaps as a consequence of diminished peripheral vascular function. Free radicals and oxidative stress have been implicated in this peripheral vascular dysfunction, as a redox imbalance may directly impact the function of the vascular endothelium. This review aims to bring together studies that have examined the impact of oxidative stress on peripheral vascular function and oxygen delivery and utilization with both healthy aging and HFrEF.

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Acknowledgments

Funded in part by HL091830 (R.S.R.), I01RX000182 (R.S.R.), I01RX001697 (R.S.R.), I21RX001433 (R.S.R.), E9275-L (R.S.R.), I21RX001572 (M.A.), HL116579 (M.A.), HL103786 (M.A.), AHA14-17770016 (M.A.), I21RX001418 (D.W.W.), and HL118313 (D.W.W.).

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Authors and Affiliations

  1. Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA

    D. Walter Wray, Markus Amann & Russell S. Richardson

  2. Geriatric Research, Education, and Clinical Center, VA Medical Center, Bldg 2, Rm 1D25, 500 Foothill Drive, Salt Lake City, UT, 84148, USA

    D. Walter Wray, Markus Amann & Russell S. Richardson

  3. Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT, USA

    D. Walter Wray, Markus Amann & Russell S. Richardson

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  1. D. Walter Wray
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  2. Markus Amann
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Correspondence to Russell S. Richardson.

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Drs. Wray, Amann, and Richardson have no conflicts of interest or financial ties to disclose.

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Wray, D.W., Amann, M. & Richardson, R.S. Peripheral vascular function, oxygen delivery and utilization: the impact of oxidative stress in aging and heart failure with reduced ejection fraction. Heart Fail Rev 22, 149–166 (2017). https://doi.org/10.1007/s10741-016-9573-4

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