Abstract
A political discourse of peace marked the distribution and use of radioisotopes in biomedical research and in medical diagnosis and therapy in the post-World War II period. This occurred during the era of expansion and strengthening of the United States’ influence on the promotion of sciences and technologies in Europe as a collaborative effort, initially encouraged by the policies and budgetary distribution of the Marshall Plan. This article follows the importation of radioisotopes by two Spanish research groups, one in experimental endocrinology and one in molecular biology. For both groups foreign funds were instrumental in the early establishment of their laboratories. The combination of funding and access to previously scarce radioisotopes helped position these groups at the forefront of research in Spain.
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References
Anderson D.L., Hackman D.D., Reilly B.E. 1966. Structure of Bacillus subtilis Bacteriophage φ29 and the Length of φ29 Deoxyribonucleic Acid Journal of Bacteriology 91: 2081–2089
Apple Toby 2000. Shaping Biology. The National Science Foundation and American biological research Johns Hopkins University Press Baltimore
Ávila, Jesús 2003. “Los isótopos radiactivos y la biología molecular en España: los trabajos pioneros del grupo de Margarita Salas y Eladio Viñuela.” In Santesmases and Romero (eds.), pp. 103–109
Ávila J., Hermoso J.M., Viñuela E., Salas M. 1970. Subunit Composition of B. subtilis RNA Polymerase Nature 226: 1244–1245
Ávila J., Hermoso J.M., Viñuela E., Salas M. 1971. Purification and Properties of DNA-Dependent RNA Polymerase from Bacillus subtilis Vegetative Cells European Journal of Biochemistry 21: 526–535
Ávila J., Perucho M., López-Otín C. (eds.) 2003. El fago φ29 y los orígenes de la biología molecular en España Consejo Superior de Investigaciones científicas Madrid
Beatty John 1991. Genetics in the Atomic Age: The Atomic Bomb Casualty Comission, 1947–1956 In Keith Benson, Reiniger R., Jane Maienschein, (eds.), The Expansion of American Biology Rutgers University Press New Brunswick, NJ pp. 284–324
Beatty John 1993. Scientific Collaboration, Internationalism, and Diplomacy: The Case of the Atomic Bomb Casualty Commission Journal of the History of Biology 26: 205–231
Beatty John 2000. Origins of the US Human Genome Project: Changing Relationships Between Genetics and National Security In Phillip R. Sloan (eds.), Controlling Our Destinies. Historical, Philosophical, Ethical and Theological Perspectives on the Human Genome Project University of Notre Dame Press Notre Dame, IN pp. 131–153
Broda Engelbert 1960. Radioactive Isotopes in Biochemistry Elsevier Amsterdam
Clause Bonny T. 1993. The Wistar Rat as a Right Choice: Establishing Mammalian Standards and the Ideal of a Standardized Mammal Journal of the History of Biology 26: 329–349
Creager Angela N.H. 2002. Tracing the Politics of Changing Postwar Research Practices: The Export of “American” Radioisotopes to European Biologists. Studies in History and Philosophy of Biological and Biomedical Sciences 33: 367–388
Creager Angela N.H. 2004. The Industrialization of Radioisotopes by the US Atomic Energy Commission In Karl Garndin, Nina Woormbs, (eds.), Science and Industry in the 20th Century, Nobel Symposium 123 Watson Publishing Canton, MA pp. 143–167
de Chadarevian Soraya 1996. Sequences, Conformation, Information: Biochemists and Molecular Biologists in the 1950s Journal of the History of Biology 29: 361–386
de Chadarevian Soraya 2002. Designs for Life: Molecular Biology After World War II Cambridge University Press Cambridge
de Chadarevian Soraya, Kamminga Harmke (eds.) 1998. Molecularizing Biology and Medicine: New Practices and Alliances Harwood Amsterdam
Eisenhower, Dwight D. 1953. “Atoms for Peace”, Address Before the General Assembly of the United Nations on Peaceful Uses of Atomic Energy, New York City, December 8, 1953. http://www.eisenhower.utexas.edu/atoms.htm
Escobar del Rey F., Morreale de Escobar G. 1958. Studies in the peripheral disappearance of thyroid hormone Acta Endocrinologica 29: 161–175
Escobar del Rey F., Morreale de Escobar G. 1961. The Effect of Propylthiouracil, Methylthiouracil and Thiouracil on the Peripheral Metabolism of l-Thyroxine in Thyroidectomized, l-Thyroxine Maintained Rats Endocrinology 69: 456–465
Escobar del Rey, Francisco and Morreale de Escobar, Gabriela 2003. “Marañón y el tiroides.” Revisión de la obra médica de Gregorio Marañón. Madrid: Fundación Santander Central Hispano-Fundación Aventis, pp. 23–101
Fischer, David 1997. History of the International Atomic Energy Agency. The First Forty Years. Vienna: The Agency. http://www-pub.iaea.org/MTCD/publications/PDF/Pub10 32_web.pdf
Fragu Philippe 2003. How the Field of Thyroid Endocrinology Developed in France After World War II Bulletin of History of Medicine 77: 393–414
Gaudillière Jean-Paul 1996. Molecular Biologists, Biochemists and Messenger RNA: The Birth of a Scientific Network Journal of the History of Biology 29: 417–445
Gaudillière Jean-Paul 2002. Inventer la biomédicine : la France, l’Amérique et la production des savoir du vivant (1945–1965) La Découvert Paris
Glick Thomas F., Hall Diana Long 1976. On the Diffusion of a New Speciality: Marañón and the Crisis of Endocrinology Journal of the History of Biology 9: 287–300
Gowing Margaret 1974. Independence and Deterrence. Britain and Atomic Energy, vol. I, Policy Making; vol. II, Policy Execution MacMillan Press London
Gros Francois, Hiatt H., Gilbert Walter, Kurland C.G., Risebrough R.W., Watson J.D. 1961. Unstable Ribonucleic Acid Revealed by Pulse Labelling of Escherichia coli Nature 190: 581–585
Gros François 1979. The Messenger. In André Lwoff, Agnes Ullman, (eds.), Origins of Molecular Biology Academic Press New York pp. 119–124
Hacking Ian 1983. Representing and Intervening Cambridge University Press Cambridge
Heilbron John L., Robert W. Seidel 1989. Lawrence and His Laboratory. A History of Lawrence Berkeley Laboratory vol. I University of California Press Berkeley-Los Angeles
Herrán, Néstor and Roqué, Xavier 2003. “Radiosiótopos en España: perspectivas historiográficas y proyectos en curso.” In Santesmases and Romero (eds.), pp. 41–52
Hevesy George 1948. Radioactive Indicators. Their Application in Biochemistry, Animal Physiology, and Pathology Interscience New York
Hewlett Richard G., Anderson Oscar E. 1962. History of the United States Atomic Energy Commission, vol. I, The New World, 1939/1946 Pennsylvania State University Press Pennsylvania
Hewlett Richard G., Duncan Francis 1969. History of the United States Atomic Energy Commission, vol. II, Atomic Shield 1947/1952 Pennsylvania State University Press Pennsylvania
Holmes Frederic L. 2002. Meselsohn, Stahl and the Replication of DNA: A History of “The Most Beautiful Experiment in Biology Yale University Press New Haven, CT
Kay Lily E. 2000. Who Wrote the Book of Life? A History of the Genetic Code Stanford University Press Stanford
Kirsch Scott 2004. Harold Knapp and the Geography of Normal Controversy: Radioiodine in the Historical Environment Osiris 19: 167–181
Kohler Robert E. 1991. Partners in Science. Foundations and Natural Scientists 1900–1945 University of Chicago Press Chicago
Kraft Alison 2006. Between Medicine and Industry: Medical Physics and the Rise of Radioisotope 1945–1965 Contemporary British History 20: 1–35
Krige John 2006a. Atoms for Peace, Scientific Internationalism and Scientific Intelligence Osiris 21: 161–181
Krige John 2006b. American Hegemony and the Postwar Reconstruction of Science in Europe MIT Press Cambridge, MA
Lain Entralgo Pedro 1969. Gregorio Marañón. Vida, obra y persona Austral Madrid
Lindee M. Susan 1994. Suffering Made Real: American Science and the Survivors at Hiroshima University of Chicago Press Chicago
Marañón Gregorio 1993. Viaje a Las Hurdes: El manuscrito inédito de Gregorio Marañón y las fotografías de la visita de Alfonso XIII El País Aguilar-Fundación Gregorio Marañón Madrid
Medina Doménech Rosa M. 1996. Curar el cáncer? Los orígenes de la radioterapia española en el primer tercio del siglo XX Universidad de Granada Granada
Medina Doménech Rosa María 1997. Scientific Rhetoric in the Consolidation of a Therapeutic Monopoly. Medical Discourses of Spanish Radiotherapists Social History of Medicine 10: 221–242
Morreale, Gabriela and Escobar, Francisco 2003. “La endocrinología experimental en España y el yodo readiactivo.” In Santesmases and Romero (eds.), pp. 89–101
Naciones Unidas 1956. Actas de la Conferencia Internacional sobre la Utilización de la Energía Atómica con Fines Pacíficos, 16 vols, vol. X, Los isótopos radiactivos y las radiaciones nucleares en medicina; vol. XI, Efectos biológicos de las radiaciones; vol.␣XII: Los isótopos radiactivos y las radiaciones ionizantes en agricultura, fisiología y bioquímica; vol. XIV, Los isótopos radiactivos: problemas generales y dosimetría; vol. XV, Los isótopos radiactivos y los productos de fisión en la investigación y en la industria. United Nations
Olagüe de Ros Guillermo 2004. La labor experimental del Laboratorio de Fisiología de la Nutrición (1947–1958) de la Cátedra de Patología General y Médica de Eduardo Ortiz de Landázuri In Martínez Pérez J., Isabel Porras M., Samblás P., del Cura M. (eds.), La medicina ante el nuevo milenio: una perspectiva histórica Universidad de Castilla-La Mancha Cuenca pp. 571–592
Ordóñez Javier, Sánchez Ron, José Manuel 1996. Nuclear Energy in Spain: From Hiroshima to the Sixties In Paul Forman, José Manuel Sánchez-Ron (eds.), National Military Establishments and the Advancement of Science and Technology. Studies in the 20th Century History Kluwer Dordrecht pp. 185–213
Palló Gábor 1981. Significant Stages in the Biochemical Research Work of György Hevesy Periodica Polytechnica Chemical Engineering 25: 1–13
Palló Gábor 1986. Why did George von Hevesy Leave Hungary Periodica Polytechnica Chemical Engineering 30: 97–115
Palló Gábor 2002. Scientific Recency: George de Hevesy’s Nobel Prize In Elisabeth Crawford, (ed.). Historical Studies in the Nobel Archives. The Prizes in Science and Medicine Universal Academic Press Tokyo pp. 65–78
Portero Florentino 1989. Franco aislado: la cuestión española Aguilar Madrid
Presas i Puig Albert 2005. Science on the Periphery. The Spanish Reception of Nuclear Energy: An Attempt at Modernity? Minerva 43: 197–218
Rader Karen 2004. Making Mice: Standardizing Animals for American Biomedical Research Princeton University Press Princeton
Rasmussen Nicolas 1997a. The Mid-Century Biophysics Bubble: Hiroshima and the Biological Revolution in America History of Science 35: 245–293
Rasmussen Nicolas 1997b. Picture Control. The Electron Microscope and the Transformation of Biology in America Stanford University Press Stanford, CA
Reilly B.E., Spizizen J. 1965. Bacteriophage Deoxyribonucleate Infection of Competent Bacillus subtillis Journal of Bacteriology 89: 782–790
Rheinberger Hans-Jörg 1997. Toward a History of Epistemic Things: Synthesizing Proteins in the Test Tube Stanford University Press Stanford
Rheinberger Hans-Jörg 2001. Putting Isotopes to Work: Liquid Scintillation Counters, 1950–1970 In Joerges B., Shinn Terry (eds.), Instrumentation Between Science and Industry Kluwer Academic Publishers Dordrecht pp. 143–174
Roca-Rosell Antoni, Sánchez Ron, José Manuel 1990. Esteban Terradas. Ciencia y técnica en la España contemporánea INTA-Serbal Madrid
Romero Ana, Sánchez Ron, José Manuel 2001. Energía Nuclear en España: de la JEN al Ciemat Ciemat Madrid
Salas M., Smith M.A., Stanley Jr W.M., Wahba A.J., Ochoa S. 1965. Direction of Reading of the Genetic Message Journal of Biological Chemistry 240: 3988–3995
Salas M., Hille M.B., Last J.A., Wahba A.J., Ochoa S. 1967. Translation of the Genetic Message. II. Effect of Initiation Factors on the Binding of Formyl-Methionyl∼tRNA to Ribosomes Proceedings of the National Academy of Sciences USA 57: 729–734
Sánchez Ron José Manuel 1997. INTA. 50 años de ciencia y técnica aeroespacial INTA Madrid
Santesmases María Jesús 2000. Severo Ochoa and the Biomedical Sciences in Spain Under Franco (1959–1975) Isis 91: 706–734
Santesmases María Jesús 2001. Entre Cajal y Ochoa: ciencias biomédicas en la España de Franco CSIC Madrid
Santesmases María Jesús 2002a. National politics and international trends: EMBO and the making of molecular biology in Spain Studies in History and Philosophy of Biological and Biomedical Sciences 33: 517–531
Santesmases María Jesús 2003. Neutralidades y atrasos: ciencias y tecnicismo en la España de Franco. Actes de la VII Trobada d’Història de la Ciència i de la Técnica SEHCT Barcelona
Santesmases María Jesús 2005. Severo Ochoa: de músculos a proteínas Síntesis Madrid
Santesmases María Jesús 2006. Delivering penicillin: The clinic, the Hero and Industrial Production in Spain, 1943–1952 In Viviane Quirke, Judy Slinn (eds.), Perspectives on 20th-Century Pharmaceuticals Peter Lang New York, Oxford (forthcoming)
Santesmases María Jesús, Muñoz Emilio 1997a Establecimiento de la bioquímica y de la biología molecular en España Fundación Ramón Areces Madrid
Santesmases María Jesús, Muñoz Emilio 1997b. Scientific Periphery and Spanish Backwardness: The Establishment of a Biomedical Discipline at the Centro de Investigaciones Biológicas (1956–1967) Minerva 35: 27–45
Santesmases María Jesús, Romero Ana (eds.) 2003. La física y las ciencias de la vida en el siglo XX: radiactividad y biología Universidad Autónoma de Madrid Madrid
Sanz-Menéndez Luis 1997. Estado, ciencia y tecnología en España Alianza Madrid
Smith M.A., Salas M, Stanley Jr W.D., Wahba A.J., Ochoa S. 1966. Direction of reading of the genetic message II Proceedings of the National Academy of Science USA 55: 141–147
Stanbury John B., Brownell Gordon, Lee Perinetti, Héctor Riggs, Douglas S. 1954. Endemic Goiter. The Adaptation of Man to Iodine Deficiency. A Report of the Andean Goiter Expedition in Mendoza, Argentina, in the Summer of 1951 Harvard University Press Cambridge, MA
Stanbury, John B. 1999. “Iodine Deficiency and Related Issues: A Personal Historical Account.” IDD [Iodine Deficiency Disorders] Newsletter 15(4). http://www.people.virgina.edu/jtd∼/iccidd/newsletter/nov1999.htm
Stanbury, John B., Morreale, Gabriela and Escobar, Francisco. 2001. “Andries Querido, obituary note.” IDD [Iodine Deficiency Disorders] Newsletter 17(2), May 2001. http://www.people.virgina.edu/jtd∼/iccidd/newsletter/idd501.htm#g
Stanley Jr. W.M., Salas M., Wahba J.A., Ochoa S. 1966. Translation of the Genetic Message: Factors Involved in the Initiation of Protein Synthesis Proceedings of the National Academy of Science USA 56: 290–295
United States Atomic Energy Commission 1949. Atomic Energy and the Life Sciences US Printing Office Washington, DC
United States Atomic Energy Commission 1955. Selected Reference Material. United States Atomic Energy Program, vol. 7, Eight-year Isotope Summary US Government Printing Office Washington, DC
Watson, James D. 1962. “The Involvement of RNA in the Synthesis of Proteins.” Nobel Lectures, Physiology or Medicine 1942–1962. Amsterdam: Elsevier, pp. 785–808
Wise, M. Norton 1995. “Introduction.” In his edited volume The Values of Precision. Princeton: Princeton University Press, pp. 3–13
Zamecnik, Paul 1969. “An Historical Account of Protein Synthesis, With Current Overtones – A Personal View.” Cold Spring Harbor Symposia of Quantitative Biology, vol. 34, The Mechanism of Protein Synthesis. New York: Cold Spring Harbor, pp. 1–16
Acknowledgments
Early research for this paper was partially funded by a grant from the Consejo de Seguridad Nuclear (Spain) and more recently by the Spanish Ministerio de Ciencia y Tecnología (BFF2003-09579-C03-03). I wish to thank Jesús Ávila, Francisco Escobar, Néstor HerrÁn, Gabriela Morreale, Emilio Muñoz, Javier Ordóñez, Hans-Jörg Rheinberger, José Manuel SÁnchez Ron, Ana Romero and Xavier Roqué for their contributions to the seminar held in Madrid in December 2002 on “Radioactivity and biology”, funded by the Spanish Consejo de Seguridad Nuclear. I am grateful to Angela Creager, who called my attention to material recorded at the archives of the US Atomic Energy Commission. Richard Rayburn kindly attended my requests at the NARA facilities, in Morrow, GA.
I also acknowledge the information provided by Margarita Salas and Gabriela Morreale, and comments and suggestions from Angela Creager, Soraya de Chadarevian, Emilio Muñoz, Javier Ordóñez and Hans-Jörg Rheinberger to an earlier version of this paper. A␣shorter version was presented at the ISHPSSB Meeting held in Vienna, July 2003.
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Santesmases, M.J. Peace Propaganda and Biomedical Experimentation: Influential Uses of Radioisotopes in Endocrinology and Molecular Genetics in Spain (1947–1971). J Hist Biol 39, 765–794 (2006). https://doi.org/10.1007/s10739-006-9112-6
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DOI: https://doi.org/10.1007/s10739-006-9112-6