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Association of interleukin-23 receptor gene polymorphisms with risk of bladder cancer in Chinese

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Abstract

To assess whether polymorphisms of the interleukin-23 receptor (IL23R) gene are associated with bladder transitional cell carcinoma because chronic inflammation contributes to bladder cancer and the IL23R is known to be critically involved in the carcinogenesis of various malignant tumors. 226 patients with bladder cancer and 270 age-matched controls were involved in the study. Polymerase chain reaction–restriction fragment length polymorphism was used for genotyping. Genotype distribution and allelic frequencies between patients and controls were compared. In all three single nucleotide polymorphisms of IL23R studied, the distribution of genotype and allele frequencies of rs10889677 differed significantly between patients and controls. The frequency of allele C of rs10889677 was significantly increased in cases compared with controls (0.2898 vs. 0.1833, odds ratio 1.818, 95 % confidence interval 1.349–2.449). The result indicates that IL23R may play an important role in the susceptibility of bladder cancer in Chinese population.

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Acknowledgments

This study was supported by National Natural Science Foundation of China (No. 81000246) and Scientific Research Foundation of the Education Department of Sichuan Province, China (No. 14ZA0187). We thank volunteers for donating their blood for this research.

Conflict of interest

The authors declare not to have any competing interests.

Author information

Authors and Affiliations

  1. Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China

    Tielong Tang, Shu Cui & Zhiyong Gong

  2. Urogenital Diseases Lab, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China

    Tielong Tang & Shulin Cheng

  3. Department of Anatomy, College of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, People’s Republic of China

    Hui Xue

  4. Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China

    Zhonghai Fei

  5. Department of Neurology, The Central Hospital of Dazhou City, Dazhou, People’s Republic of China

    Chunyan Gui

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  1. Tielong Tang
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  2. Hui Xue
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  3. Shu Cui
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Corresponding author

Correspondence to Tielong Tang.

Additional information

Tielong Tang and Hui Xue have contributed equally to this work.

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Tang, T., Xue, H., Cui, S. et al. Association of interleukin-23 receptor gene polymorphisms with risk of bladder cancer in Chinese. Familial Cancer 13, 619–623 (2014). https://doi.org/10.1007/s10689-014-9731-6

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  • DOI: https://doi.org/10.1007/s10689-014-9731-6

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