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Factors affecting the decision to undergo risk-reducing salpingo-oophorectomy among women with BRCA gene mutation

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Abstract

The objective of this study was to identify factors that affect the decision to undergo risk-reducing salpingo-oophorectomy (RRSO) in BRCA1 or BRCA2 mutations carriers in South Korea. The medical records of 124 women who had been found to have BRCA1 or BRCA2 gene mutation at our institution between May 2003 and December 2011 were reviewed. The carriers were divided into RRSO and non-RRSO groups for comparison of their clinicopathologic, socio-economic, and psychosocial factors. Of the 71 carriers eligible for RRSO, 21 had undergone RRSO. In univariate analysis, classification of carriers into 3 groups by decade of life (4th, 5th, or 6th and later decade) and subsequent analysis revealed that 52.6 % of carriers in the 5th decade had undergone RRSO, a rate significantly higher than that of the other age groups (p = 0.007). The RRSO rate was higher in carriers with a personal history of breast cancer than in those without (39.2 % vs. 5.0 %, p = 0.004), in carriers with a family history of breast cancer than in those without (35.5 % vs. 11.8 %, p = 0.065), and in carriers with a family history of ovarian cancer than in those carriers without a family history (66.7 % vs. 24.2 %, p = 0.016). Multivariate analysis identified age and personal history of breast cancer as independent factors affecting the decision to undergo RRSO. Age and personal history of breast cancer are important factors in the decision to undergo, and should thus be considered when counseling BRCA1/2 mutation carriers.

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Acknowledgments

This study was supported by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea (1020350).

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  1. Department of Surgery, Seoul National University Bundang Hospital, 300 Gumidong, Bundanggu, Seongnamsi, Gyeonggido, 463-707, Korea

    Dongwon Kim, Eunyoung Kang, Euijun Hwang, Young Sun, Yoonsun Hwang, Cha Kyong Yom & Sung-Won Kim

  2. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, 300 Gumidong, Bundanggu, Seongnamsi, Gyeonggido, 463-707, Korea

    Kidong Kim, Jae Hong No & Yong-Beom Kim

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Kim, D., Kang, E., Hwang, E. et al. Factors affecting the decision to undergo risk-reducing salpingo-oophorectomy among women with BRCA gene mutation. Familial Cancer 12, 621–628 (2013). https://doi.org/10.1007/s10689-013-9625-z

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