Summary
Purpose Recall dermatitis is a rare and poorly understood drug-related event. Activated by exposure to sunlight or Ultraviolet (UV), drug-related phototoxic reactions have been reported with conventional chemotherapy agents or antibiotics. Methods Here, we report the first case of acute dermatologic photo-induced recall reaction secondary to sorafenib in a patient with renal cell carcinoma. Results Four weeks after stopping sorafenib, a patient with renal cell carcinoma developed an acute erythematous and papulomatous eruption restricted to the hands after prolonged solar exposure. The erythematous region was very well demarcated, mimicking the cutaneous syndrome that the patient had presented at time he was receiving sorafenib. Conclusions The suppression of the phototoxic reaction by corticosteroids strongly suggests that the immune system may have an important function in photo-recall reactions.
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References
Azria D, Magné N, Zouhair A et al (2005) Radiation recall: a well recognized but neglected phenomenon. Cancer Treat Rev 31:555–570
Badger J, Kang S, Uzieblo A, Srinivas S (2005) Double diagnosis in cancer patients and cutaneous reaction related to gemcitabine: CASE 3. Photo therapy recall with gemcitabine following ultraviolet B treatment. J Clin Oncol 23:7224–7225
Borroni G, Vassallo C, Brazzelli V et al (2004) Radiation recall dermatitis, panniculitis, and myositis following cyclophosphamide therapy: histopathologic findings of a patient affected by multiple myeloma. Am J Dermatopathol 26:213–216
Camidge DR, Kunkler IH (2000) Docetaxel-induced radiation recall dermatitis and successful rechallenge without recurrence. Clin Oncol 12:272–273
Chung C, Dawson LA, Joshua AM, Brade AM (2010) Radiation recall dermatitis triggered by multi-targeted tyrosine kinase inhibitors: sunitinib and sorafenib. Anticancer Drugs 21:206–209
Cho S, Breedlove JJ, Gunning ST (2008) Radiation recall reaction induced by levofloxacin. J Drugs Dermatol 7:64–67
Dawson GA, Brown SI, Tellefsen L (2009) A drug-related phototoxic réaction and its possible Relationship to a radiation-induced skin réaction. Oncologist 14:303–306
Ee HL, Yosipovitch G (2003) Photo recall phenomenon: an adverse reaction to taxanes. Dermatology 207:196–198
Goldfeder KL, Levin JM, Katz KA, Clarke LE, Loren AW, James WD (2007) Ultraviolet recall reaction after total body irradiation, etoposide, and methotrexate therapy. J Am Acad Dermatol 56:494–499
Kodym E, Kalinska R, Ehringfeld C, Sterbik-Lamina A, Kodym R, Hohenberg G (2005) Frequency of radiation recall dermatitis in adult cancer patients. Onkologie 28:18–21
Magné N, Benezery K, Otto J, Namer M, Lagrange JL (2002) Radiation recall dermatitis after docetaxel and external beam radiotherapy. Report of two cases and review of the literature. Cancer Radiothér 6:281–284
Pierfitte C, Royer RJ, Moore N et al (2000) The link between sunshine and phototoxicity of sparfloxacin. Br J Clin Pharmacol 49:609–612
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Magné, N., Chargari, C., Auberdiac, P. et al. Ultraviolet recall dermatitis reaction with sorafenib. Invest New Drugs 29, 1111–1113 (2011). https://doi.org/10.1007/s10637-010-9476-5
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DOI: https://doi.org/10.1007/s10637-010-9476-5