Digestive Diseases and Sciences

, Volume 60, Issue 7, pp 2030–2037

Genetic Variants in Interleukin-28B Are Associated with Diabetes and Diabetes-Related Complications in Patients with Chronic Hepatitis C Virus Infection

  • Fasiha Kanwal
  • Donna L. White
  • Li Jiao
  • Shahriar Tavakoli-Tabasi
  • Shubhada Sansgiry
  • David J. Ramsey
  • Jill Kuzniarek
  • Andrew Spiegelman
  • Hashem B. El-Serag
Original Article

DOI: 10.1007/s10620-015-3545-8

Cite this article as:
Kanwal, F., White, D.L., Jiao, L. et al. Dig Dis Sci (2015) 60: 2030. doi:10.1007/s10620-015-3545-8

Abstract

Background

Few studies have shown that host interleukin-28B (IL28B) genetic polymorphisms are associated with insulin resistance in patients with chronic hepatitis C virus (HCV) infection. However, the clinical relevance of this relationship is unclear.

Aims

We examined the association between IL28B genotype for rs12980275 and risk of type 2 diabetes and diabetes-related complications.

Methods

We used a cross-sectional study of prospectively recruited male veterans with chronic HCV. We employed logistic regression analysis and adjusted for patients’ age, race, body mass index, and hepatic fibrosis.

Results

A total of 528 participants were recruited (mean age 59.1 years; 38.5 % African-American; 40.3 % advanced fibrosis). Of these, 36.1 % were homozygous for favorable AA allele for rs12980275, 49.0 % were heterozygous (AG), and 14.0 % were homozygous for the unfavorable allele (GG). Prevalence of diabetes was significantly lower in patients with both favorable alleles (AA) than that with at least one unfavorable IL28B G allele (21.1 vs. 30.2 %, p = 0.02). Similarly, patients who were homozygous for the favorable alleles had lower prevalence of diabetes-related complications than patients with any unfavorable IL28B allele (5.7 vs. 12.2 %, p = 0.01). This association did not change after adjusting for sociodemographic characteristics, body mass index, and stage of hepatic fibrosis (adjusted ORdiabetes 0.56, 95 % CI 0.35–0.89; ORdiabetes-related complications 0.47, 95 % CI 0.23–0.96).

Conclusions

Patients who have favorable AA IL28B alleles have a lower prevalence of diabetes and related complications compared with patients with unfavorable IL28B rs12980275 genotype. IL28B genotype information may be used to counsel HCV patients regarding their individualized risk of diabetes and diabetes-related complications.

Keywords

IL28B Metabolic Single nucleotide polymorphism Insulin resistance 

Copyright information

© Springer Science+Business Media New York (Outside the USA) 2015

Authors and Affiliations

  • Fasiha Kanwal
    • 1
    • 2
    • 3
    • 4
    • 6
  • Donna L. White
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Li Jiao
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Shahriar Tavakoli-Tabasi
    • 1
    • 7
    • 6
  • Shubhada Sansgiry
    • 3
    • 6
  • David J. Ramsey
    • 1
    • 3
    • 6
  • Jill Kuzniarek
    • 1
    • 3
    • 6
  • Andrew Spiegelman
    • 8
    • 6
  • Hashem B. El-Serag
    • 1
    • 2
    • 3
    • 4
    • 6
  1. 1.Clinical Epidemiology and Comparative Effectiveness Program, Section of Health Services Research (IQuESt), Michael E. DeBakey VA Medical CenterBaylor College of MedicineHoustonUSA
  2. 2.Section of Gastroenterology and Hepatology, Department of Medicine, Michael E. DeBakey Veterans Affairs Medical CenterBaylor College of MedicineHoustonUSA
  3. 3.Section of Health Services Research, Department of MedicineBaylor College of MedicineHoustonUSA
  4. 4.Texas Medical Center Digestive Disease CenterHoustonUSA
  5. 5.Center for Translational Research on Inflammatory Diseases (CTRID)Michael E. DeBakey Veterans Affairs Medical CenterHoustonUSA
  6. 6.Section of Infectious Diseases, Hepatitis C ClinicMichael E. DeBakey Veterans Affairs Medical CenterHoustonUSA
  7. 7.Section of Infectious Diseases, Department of MedicineBaylor College of MedicineHoustonUSA
  8. 8.Department of Defense and Veterans Administration Vision Center of ExcellenceWashingtonUSA