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Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia

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Chemistry of Natural Compounds Aims and scope

A new amide, beilschamide (1), has been isolated from the stem of Beilschmiedia erythrophloia, together with seven known compounds, N-trans-feruloyltyramine (2), N-trans-feruloyloctopamine (3), vanillin (4), α-tocopheryl quinone (5), β-sitostenone (6), β-sitosterol (7), and 6α-hydroxystigmast-4-en-3-one (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. N-trans-Feruloyloctopamine (3) and beilschamide (1) exhibited cytotoxic effects with IC50 values of 10.3 and 21.2 μg/mL, respectively, against CCRF-CEM cell line.

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Acknowledgment

This research was supported by Grants from the National Science Council of the Republic of China (No. NSC 98-2320-B-127-001-MY3 and NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen.

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Authors and Affiliations

  1. Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, 907, Pingtung, Taiwan

    Jih-Jung Chen, Dau-Chang Wei & Jhy-Yih Chen

  2. Chung-Jen Junior College of Nursing, Health Sciences and Management, 600, Chiayi, Taiwan

    Wen-Lung Kuo

  3. National Museum of Marine Biology and Aquarium, 944, Pingtung, Taiwan

    Ping-Jyun Sung

  4. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 807, Kaohsiung, Taiwan

    Ih-Sheng Chen

  5. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  6. School of Pharmacy, College of Pharmacy, China Medical University, 404, Taichung, Taiwan

    Yun-Ping Lim

  7. Graduate Institute of Natural Products, Chang Gung University, 333, Taoyuan, Taiwan

    Hsiang-Ruei Liao

  8. Laboratory of Infectious Disease and Immunology, Kaohsiung Veterans General Hospital, 813, Kaohsiung, Taiwan

    Tsung-Hsien Chang

Authors
  1. Jih-Jung Chen
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  2. Wen-Lung Kuo
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  4. Ih-Sheng Chen
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  5. Ming-Jen Cheng
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  7. Hsiang-Ruei Liao
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  8. Tsung-Hsien Chang
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  9. Dau-Chang Wei
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  10. Jhy-Yih Chen
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2015, pp. 266–268.

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Chen, JJ., Kuo, WL., Sung, PJ. et al. Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia . Chem Nat Compd 51, 302–305 (2015). https://doi.org/10.1007/s10600-015-1265-0

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  • DOI: https://doi.org/10.1007/s10600-015-1265-0

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